Prophylactic Antibiotics After Cesarean

17-0035

The purpose of this study is to determine if the addition of a 48-hour course of post-operative antibiotics to the recommended course of pre-operative antibiotics improves surgical site infection rate in patients who are obese and undergo Cesarean section after laboring.

2017-08-01

2023-07-21

2023-07-21

Completed

Early phase I

321

Inclusion Criteria: * Women \>18 and \<50 years * BMI \>30kg/m2 * Decision by clinical team to perform Cesarean section * Rupture of membranes (ROM) \< 24 hours after onset of labor or during the course of labor (ROM defined by spontaneous or artificial rupture of the amniotic sac) Exclusion Criteria: * Subject unwilling or unable to provide consent * No prenatal care or a non-UTMB subject who is unlikely to be followed up after delivery * Fetal demise or major congenital anomaly * Immunosuppressed subjects: i.e., taking systemic immunosuppressants or steroids (e.g. transplant subjects; not including steroids for lung maturity), HIV with CD4\<200, or other * Diagnosis or suspicion of chorioamnionitis prior to randomization * Other planned post-operative antibiotic administration * High likelihood of additional surgical procedure beyond cesarean (e.g. scheduled hysterectomy, bowel or adnexal surgery) * Known allergy or contraindication to cephalosporins or metronidazole * Incarcerated individuals

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2023-08-16