Administration of Rectal Acetaminophen During Oocyte Retrievals Reduces Post-Operative Opioid Utilization in Fertility Patients.

STUDY005325

As the opioid epidemic shows no sign of abating, this national crisis deserves careful attention from all medical subspecialties. This includes reproductive endocrinology and infertility (REI), where opioids are primarily utilized for intraoperative and postoperative pain management for outpatient procedures such as oocyte retrievals, operative hysteroscopy, and laparoscopic myomectomy. The primary aim of this study is to evaluate whether or not the administration of rectal acetaminophen as an alternative analgesic at the completion of oocyte retrieval would reduce postoperative utilization of opioids (Tylenol with oxycodone) in fertility patients. This trial has the potential to provide practice-changing clinical information to the field of REI. The information gained can even translate to other ambulatory procedures and guide clinical practice. Primary objective of the study will be to identify the proportion of prescribed Acetaminophen and Narcotics utilized 3 days following oocyte retrieval.

2023-08-01

2024-08-01

2025-08-01

Not yet recruiting

78

Inclusion Criteria: Any female patient undergoing oocyte retrieval by transvaginal ultrasound-guided ovarian puncture. - Exclusion Criteria: 1. Patients with chronic pain conditions such as fibromyalgia and sickle cell anemia. 2. Patient with BMI greater than 40 3. Patients undergoing transabdominal ultrasound guided oocyte retrieval 4. Patients that required general endotracheal intubation anesthesia in prior oocyte retrieval. 5. Patients with documented allergic reaction to acetaminophen or oxycodone 6. Patient with contra-indication to the use of acetaminophen (liver disease) 7. Patients with a history of past or current alcohol, drug or opioid abuse. 8. Patients with ulcerative colitis, Crohn's disease, or severe rectal hemorrhoids. 9. Patients who develop complication such as PID post procedure. -

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2023-08-14