Randomized Prospective Study Comparing Exparel Erector Spinae Plane Block vs Simple Bupivacaine Erector Spinae Plane Block vs Exparel Surgeon Infiltration for Postoperative Analgesia Following Video-assisted Thoracoscopic Surgery

1809656804

The study is comparing the difference between erector spinae block and surgeon infiltration after VATS (Video Assisted Thoracoscopic Surgery). The outcomes measured are pain scores, opioid usage, opioid side effects, and patient satisfaction.We are also also studying the effectiveness of liposomal bupivacaine (EXPAREL) in a block by randomizing patients to both EXPAREL erector spinae block and simple bupivacaine erector spinae block.

2019-02-07

2022-11-06

2022-11-07

Completed

Early phase I

125

Inclusion Criteria: * Pt undergoing VATS including but not limited to wedge or lobectomy at Indiana University Hospital * ASA 1,2,3 or 4 * Age 18 or older, male or female * Desires regional anesthesia for postoperative pain control Exclusion criteria: * Any contraindication for Erector Spinae Plane block * History of substance abuse in the past 6 months which would include heroin, marijuana or any other illegal street drugs * Patient staying intubated after surgery * Patient (home dose) taking more than 30mg PO morphine equivalent per day * Known allergy or other contraindications to the study medications, which include dilaudid and bupivacaine. * Pts. scheduled for a pleurodesis, decortication or esophagectomy at Indiana University Hospital

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Patients are randomized into one of three groups:\n\n1. Ultrasound guided LB Erector Spinae Plane Block with 20ml of Exparel and 10ml 0.25% bupivacaine\n2. Ultrasound guided SB Erector Spinae Plane Block with 30ml 0.5% bupivacaine\n3. Surgeon Infiltration under video guidance with 20ml of Exparel and 10ml of 0.25% bupivacaine', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 125, 'type': 'ACTUAL'}}

2023-08-16