Clinical trial
The UMPALA Study: A Clinical Study to Assess the Impact of Contraceptives on the Cervico-Vaginal Mucosa
Name
CONRAD D20-149
Description
UMPALA is a research study to look at the effect of four different, approved contraceptives on the cervical and vaginal tissues as well as on factors in the blood. Participants will have a baseline examination then receive one of four approved, marketed contraceptive products. Cervico-vaginal assessments will take place 4 weeks after contraceptive initiation and 3 months after to assess changes in mucosal safety after use of various contraceptive products in young, healthy, HIV uninfected women.
Trial arms
Trial start
2021-03-01
Estimated PCD
2022-12-15
Trial end
2022-12-15
Status
Completed
Phase
Early phase I
Treatment
Copper IUD
Participants randomized to Copper IUD will receive Paragard IUD at Visit 2.
Arms:
Copper IUD
Other names:
Paragard
Etonogestrel implant
Participants randomized to ETG implant will receive the implant at Visit 2.
Arms:
Etonogestrel Implant
Other names:
Nexplanon, Implanon
Levonorgestrel IUS
Participants randomized to LNG intrauterine system will receive the IUS at Visit 2.
Arms:
Levonorgestrel IUS
Other names:
Mirena, Liletta
DMPA Sub-cutaneous
Participants randomized to DMPA SC will receive the injection at Visit 2.
Arms:
DMPA Sub-cutaneous
Other names:
Subcutaneous depot medroxyprogesterone acetate
Size
112
Primary endpoint
Number of participants with changes to mucosal function
4 weeks and 3 months after product use
Number of participants with changes to mucosal health
4 weeks and 3 months after product use
Eligibility criteria
Inclusion Criteria:
* Age 18 to 50 years, inclusive
* In general good health without any significant systemic disease and with an intact uterus and cervix.
* History of Pap smears and follow-up consistent with standard, local clinical practice or willing to undergo a Pap smear at Visit 1
* Willing to give voluntary consent and sign an informed consent form
* Willing and able to comply with protocol requirements, including accepting randomization to study contraceptive products
* If currently on a contraceptive product, willing to go off products and use condoms for birth control for a specified time
* If in a relationship, must be with a partner who is not known to be HIV positive and has no know risk of sexually transmitted infections (STIs)
Exclusion Criteria:
* Positive pregnancy test or plans to become pregnant during the course of the study
* Currently exclusively breastfeeding or planning to exclusively breastfeed during the course of the study
* Less than six weeks from a delivery of an infant greater than 20 weeks gestation
* Use of DMPA in the past 4 months
* Clinical signs and symptoms of menopause
* Current WHO or CDC medical eligibility criteria level 3 or 4 for any contraceptive product to which a participant could receive at the clinical site
* History of sensitivity/allergy to any component of the study product, topical anesthetic, or to both silver nitrate and Monsel's solution
* Current infection with Trichomonas vaginalis (TV), Neisseria gonorrhea (NG), Chlamydia trachomatis (CT)
* Current positive test for HIV
* History of a pulmonary embolus or deep vein thrombosis
* Chronic or acute vulvar or vaginal symptoms (pain, irritation, spotting/bleeding, discharge, etc)
* Known blood disorder, eg. von Willebrands disease, that could lead to prolonged or continuous bleeding with biopsy
* Chronic use systemic corticosteroids, antibiotics, antimycobacterials, anticoagulants or other drugs known to prolong bleeding and/or promote clotting, antifungals, or antivirals or antiretrovirals.
* Current or anticipated chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) or acetaminophen for the duration of the study
* Participation in any other investigational trial with use of a drug/device within the last 30 days or planned participation in any other investigational trial with use of a drug/device during the study
* Abnormal finding on laboratory or physical examination or a social or medical condition in which, in the opinion of the investigator, would make participation in the study unsafe or would complicate interpretation of the data
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'NON_RANDOMIZED', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Participants at each site will receive one of four marketed, approved contraceptive products for the duration of the study.', 'primaryPurpose': 'BASIC_SCIENCE', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 112, 'type': 'ACTUAL'}}
Updated at
2023-08-25
1 organization
4 products
3 indications
Organization
Eastern Virginia Medical SchoolProduct
Copper IUDIndication
Mucosal InflammationIndication
Contraceptive ComplicationsIndication
IntrauterineProduct
EtonogestrelProduct
LevonorgestrelProduct
DMPA