Clinical trial
Denosumab to Prevent High-Turnover Bone Loss After Bariatric Surgery
Name
20187525
Description
Bariatric surgery leads to bone loss and increases fracture risk. This study evaluates whether denosumab can prevent the high-turnover bone loss that occurs after Roux-en-Y Gastric Bypass (RYGB) and sleeve gastrectomy (SG) surgery.
Trial arms
Trial start
2020-08-24
Estimated PCD
2024-08-01
Trial end
2024-08-01
Status
Active (not recruiting)
Phase
Early phase I
Treatment
Denosumab
Denosumab will be administered at postoperative months 1, 7, and 13
Arms:
Denosumab
Other names:
Prolia
Placebo
Placebo will be administered at postoperative months 1, 7, and 13
Arms:
Placebo
Zoledronic Acid
Zoledronic Acid 5mg will be administered intravenously at postoperative month 19
Arms:
Denosumab, Placebo
Other names:
Reclast
Size
36
Primary endpoint
Percentage change in total hip bone mineral density
Pre-operative baseline to post-operative month 19
Eligibility criteria
Inclusion criteria:
* Postmenopausal women who are planning RYGB or SG surgery
* Men aged ≥ 50 years who are planning RYGB or SG surgery
Exclusion criteria:
* Prior bariatric surgery
* Weight = 400 lbs (due to limitations of bone imaging equipment)
* Renal disease
* Hypercalcemia or hypocalcemia
* Hypomagnesemia
* Serum 25-OH vitamin D (25OHD) \< 20 ng/mL
* Hyperparathyroidism
* Liver disease (AST or ALT \> 2 x upper normal limit)
* HCT \< 32%
* History of malignancy (except basal cell carcinoma) in the past 1 year
* Significant cardiopulmonary disease
* Major psychiatric disease
* History of celiac disease or inflammatory bowel disease
* Excessive alcohol or substance abuse
* Paget's disease, primary hyperparathyroidism, or any other known congenital or acquired bone disease other than osteoporosis
* Current hyperthyroidism or use of levothyroxine with TSH \< 0.1 uIU/mL
* Current use of loop diuretics
* Current use or use in the past 12 months of oral bisphosphonates or DMAB
* Current use or use within the past 3 months of SERMs or calcitonin
* Current use or use within the past 3 months of estrogen
* Use of testosterone therapy if dose has changed within the last 3 months, or if dose change or discontinuation is planned in the upcoming 18 months
* Any current or previous use of teriparatide, strontium, or any parenteral bisphosphonate
* Use of oral or parenteral glucocorticoids for more than 14 days within the past 6 months
* Extensive dental work involving extraction or dental implant within the past 2 months or planned in the upcoming 18 months
* DXA BMD T-score of \< -3.0 at PA spine, total hip, or femoral neck
* Current use of anti-VEGF drug
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'PREVENTION', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 36, 'type': 'ACTUAL'}}
Updated at
2023-10-18
1 organization
2 products
1 drug
2 indications
Organization
Massachusetts General HospitalProduct
DenosumabIndication
Bariatric Surgery CandidateIndication
OsteoporosisDrug
VarlilumabProduct
Zoledronic Acid