Hydration Dynamics and Influence of Beverage Composition

2021-0823

The study examines interactions between fluid availability in the gut and fluid retention in the body. The relative rate of fluid uptake, the expansion of the plasma volume, and percent of fluid retained by the body will be measured in response to ingestion of beverages of different composition. Healthy, euhydrated adults will be studied. The results will help establish formulations of beverages that sustain if not promote acute euhydration.

2021-09-03

2022-10-31

2022-11-30

Completed

Early phase I

14

Inclusion Criteria: * Have a BMI of 18.5 to 29.9 kg/m2. * Be normotensive (\<120/80 mm Hg). * Must be able to speak and read English. * Be physically active or a regular exerciser but be able to abstain from exercise for 48 h prior to each study trial. * Fast for at least 8 hours prior to and through the study trial. * Be able to abstain from alcohol for 48 h prior to each study. * Be able to abstain from caffeine for 24 h prior to each study. * If female, must have regular menstrual cycles, that are \> 27 days and \< 35 days in length. Exclusion Criteria: * Under 18 y of age or over 45 y of age. * Have a BMI \<18.5 or \>30. * Being pregnant. * Lactating. * Tobacco user. * Have hypotension or hypertension. * Have any type of kidney disease or dysfunction. * Have diabetes. * Have any type of cardiovascular disease. * Have been diagnosed with galactosemia. * Females with irregular menstrual cycles. * Females with polycystic ovary disease.

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1', 'PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'CROSSOVER', 'interventionModelDescription': 'Mixed model.', 'primaryPurpose': 'PREVENTION', 'maskingInfo': {'masking': 'SINGLE', 'maskingDescription': 'Beverages will have similar color, flavoring, and taste.', 'whoMasked': ['PARTICIPANT']}}, 'enrollmentInfo': {'count': 14, 'type': 'ACTUAL'}}

2023-07-14