Longitudinal Changes in Eye Shape in Young Adults Treated With Low-Dose Atropine and Soft Multifocal Contact Lenses

2023H0321

The goal of this clinical trial is to study changes in eye shape of nearsighted young adults using low-dose atropine eye drops or soft multifocal contact lenses. The main questions it aims to answer are: * do low-dose atropine and soft multifocal contact lenses affect the shape of the peripheral eye? * are changes in peripheral eye shape from these interventions influenced by changes in the focusing system of the eye? Participants will: * have multiple different types of photos taken * have their prescription for glasses/contacts checked * have their eye health checked, including the use of dilating eye drops * be randomly assigned to use eye drops every night or wear special contact lenses daily instead of their typical contacts * will complete five study visits over the course of 12 months Researchers will compare young adults using low-dose atropine to those wearing soft multifocal contact lenses and to those using no intervention to see if using these interventions affects retinal shape.

2024-07-01

2025-10-31

2025-12-31

Not yet recruiting

Early phase I

75

Inclusion Criteria: * best corrected visual acuity of 20/25 or better in each eye * nearsighted * current contact lens wearer * normal binocular vision (to be determined by an examiner at the first study visit) Exclusion Criteria: * eye diseases (including lazy eye or eye turn) * pregnant, nursing, or planning a pregnancy in the next 12 months * history of refractive surgery (e.g., LASIK) * history of myopia control treatment * sensitivity to anesthetics or preservative in eye drops * difficulty with pupillary dilation

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2024-06-10