Clinical trial

The Effect of Intramuscular Injection of Triple Doses of Human Chorionic Gonadotropin in Frozen Embryo Transfer Cycles

Name

FET-HCG

Description

This study is a randomized controlled clinical trial to compare the pregnancy outcomes of infertile women with frozen embryo transfer. The study population in frozen embryo transfer cycles receive three doses of human chorionic gonadotropin (HCG) to recognize the effectiveness of HCG on pregnancy outcomes in Reproductive Biomedicine Research Center, Royan institute, Tehran Iran.

Trial arms

Trial start

2020-07-01

Estimated PCD

2022-08-22

Trial end

2023-06-20

Status

Completed

Treatment

The effect of intramuscular injection of triple doses of human chorionic gonadotropin in frozen embryo transfer cycles

Patients receive 5,000 IU of human chorionic gonadotropin by intramuscular injection, 72 hours before embryo transfer, on the day of embryo transfer, and 72 hours after embryo transfer.

Arms:

The group of frozen embryo transfer with intramuscular injection of human chorionic gonadotropin.

Other names:

The effect of intramuscular injection of triple doses of human chorionic gonadotropin on embryo implantation

Size

200

Primary endpoint

Rate of Implantation

6 weeks after embryo transfer

Eligibility criteria

Inclusion Criteria: * Infertile women candidates for frozen embryo transfer * Age 20-40 years * Body Mass Index under than 30 Kg/m2 * Having at least three good quality embryos Exclusion Criteria: * Women with hematologic and autoimmune disorders * Couples with chromosomal and genetic abnormalities * Women with uterine anomalies * Women with uterine and ovaries surgical history * Women with endometriosis and adenomyosis * Women with hydrosalpinx * Women with uterine fibroids * Women with history of recurrent abortion or recurrent implantation failure * Severe male factor infertility (azoospermia) * Embryo donation cycle * Endometrial thickness less than 8 millimeter on the day of embryo transfer

Protocol

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 200, 'type': 'ACTUAL'}}

Updated at

2024-01-05

1 organization

1 product

1 indication

Organization

Royan Institute

Product

Human Chorionic Gonadotropin

Indication

Embryo Implantation