Clinical trial
Antibiotic Prophylaxis in High-Risk Arthroplasty Patients
Name
22-001273
Description
To determine the effectiveness of a 7-day course of an oral, prophylactic antibiotic on the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk patient population.
Trial arms
Trial start
2020-06-11
Estimated PCD
2025-06-01
Trial end
2025-06-01
Phase
Early phase I
Treatment
Cephalexin
500 mg oral tablet, 4 times daily for 7 days
Arms:
Additional Antibiotic Group
Other names:
Keflex
Doxycycline
100 mg oral tablet, 2 times daily for 7 days
Arms:
Additional Antibiotic Group
Cefadroxil
500 mg oral tablet, 2 times daily for 7 days
Arms:
Additional Antibiotic Group
Other names:
Duricef
Size
4618
Primary endpoint
Periprosthetic joint infections
Within 90-days primary hip or knee arthroplasty
Periprosthetic joint infections
Within 1-year of primary hip or knee arthroplasty
Eligibility criteria
Inclusion Criteria:
* Patient is a candidate for elective, primary total hip arthroplasties (THA) or total knee arthroplasties (TKA).
* Patient is considered high-risk for developing Periprosthetic joint infections (PJI) based on having at least one of the following criteria:
* Body mass index (BMI) \> 35 kg/m\^2;
* Diagnosis of diabetes mellitus;
* Active tobacco smoker;
* Chronic kidney disease;
* Autoimmune disease;
* Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-sensitive Staphylococcus aureus (MSSA).
Exclusion Criteria:
* Inability to consume oral antibiotics.
* Allergy to antibiotic alternatives in the protocol.
* History of clostridium difficile colitis.
* Revision hip or knee arthroplasty procedure.
* Non-elective surgery.
* Hemiarthroplasty.
* Unicompartmental knee arthroplasty.
* Simultaneous bilateral THA or TKA.
* Will have subsequent THA or TKA within 12 weeks of the index study procedure.
* Pregnant.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'PREVENTION', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 4618, 'type': 'ESTIMATED'}}
Updated at
2023-06-28
1 organization
3 products
9 indications
Organization
Mayo ClinicProduct
CephalexinIndication
Infections Joint ProstheticIndication
ObesityIndication
MRSAIndication
Chronic Kidney DiseaseIndication
DiabetesIndication
Autoimmune DiseasesIndication
Inflammatory DiseaseIndication
Tobacco UseProduct
DoxycyclineProduct
Cefadroxil