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Clinical trial

Comparison Between the Effect of Spinal Bupivacaine Versus Spinal Prilocaine on Maternal Blood Pressure in Cesarean Section

ID
Name
Prilocaine in cesarean section
Description
one of the most common complications associated with spinal anesthesia is hypotension, which can have adverse effects on both the mother and the fetus. The present study compare prilocaine versus bupivacaine in spinal anesthesia on hypotension and there effect on maternal outcomes.
Trial arms
Trial start
2024-05-01
Estimated PCD
2024-11-01
Trial end
2024-12-01
Status
Not yet recruiting
Treatment
Bupivacaine
Spinal anesthesia with standard dose of bupivacaine
Arms:
Group B
Other names:
Intrathecal Bupivacaine
Prilocaine
Spinal anesthesia with 50 mg dose of Prilocaine.
Arms:
Group P
Other names:
Intrathecal prilocaine
Size
60
Primary endpoint
Maternal arterial blood pressure
at base line before induction and every 3 minute during the first 15 min after spinal then every 5 mins until the end of surgery and every 1 hour postoperatively for 6 hours
Eligibility criteria
Inclusion Criteria: * Pregnant \>36 weeks singleton baby * American Society of Anesthesiologists (ASA) physical status 2 * Age : between 18 years old and 35 years old Exclusion Criteria: * Pregnant women with cardiac disease and history of psychiatric illness * Pregnant women who received spinal anesthesia and converted to general anesthesia * Women who have sensitivity to local anesthetics, * Women who have Eclampsia, abruption placenta or placenta previa * Women who have coagulopathy, thrombocytopenia with platelet count less than 80,000/cm3, myasthenia
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'OTHER', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 60, 'type': 'ESTIMATED'}}
Updated at
2024-03-05

1 organization

2 products

1 indication

Organization
South Valley University
Product
Bupivacaine
Indication
Adverse Effects of Spinal Anesthetics
Product
Prilocaine