Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients: A Randomized Double-Blind Controlled Study

Management of Fever in Sepsis

This is a randomized double-blind controlled study with the primary aim of scientifically evaluating the potential effects of paracetamol and ibuprofen in the management of sepsis by comparing their fever-reducing efficacy in septic patients. Sepsis is recognized as a severe form of systemic inflammatory response syndrome (SIRS) characterized by organ dysfunction resulting from severe infections. This study aims to address a significant aspect of fever management in septic patients by objectively assessing the fever-reducing potential of paracetamol and ibuprofen.

2023-10-31

2024-10-31

2024-12-01

Recruiting

Early phase I

84

Inclusion Criteria: * 18 years of age or older * Under 80 years of age * Willing to participate in the study * Diagnosed with sepsis according to the latest current guidelines * Having a fever \>38°C * With no known history of adverse reactions to the active ingredient of the medication to be used" Exclusion Criteria: * Under 18 years of age or over 80 years of age * Not willing to participate in the study * With a known history of adverse reactions to study medications * Having a fever \<38°C * Pregnant individuals * Individuals with advanced systemic illness * Those with malignancies * Patients with chronic liver and kidney disease * Using sedative and analgesic neuro-psychiatric drugs * With a history of psychological and neurological diseases"

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 84, 'type': 'ESTIMATED'}}

2024-01-08