Effect of Local Application of Platelet-Rich Fibrin Scaffold Loaded With Simvastatin Versus Bone Powder on Peri-Implant Bone Changes

260981

This study is conducted A- To investigate that PRF loaded with osteopromotive pharmacological drug can be a great aid in implant rehabilitation, and whether it could be a replacement for the other high price bone graft materials or not. This will be done through: 1. Measuring bone changes around the implant by cone beam 2. Measuring change in bone density around the implants B- Evaluate the effect of statins on osteoblasts activity and expression of various osteogenic products in vitro.

2021-01-05

2022-01-05

2023-02-05

Completed

Early phase I

24

Inclusion Criteria: * Badly Broken Down Tooth requiring extraction * Medically Free * Any other procedures or surgeries were performed 6 months earlier Exclusion Criteria: * patients with systemic diseases affecting bone quality or resorption * temporomandibular joint dysfunction * severe attrition or parafunctional habits * patients undergoing radiotherapy or chemotherapy * heavy smokers * vulnerable groups like psychologically unstable patients.

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1', 'PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 24, 'type': 'ACTUAL'}}

2023-09-06