A Cross-sectional Study on the Efficacy and Safety of the Combination of Daratumumab+Bortezomib+Dexamethasone Regimen and Dapagliflozin in the Treatment of M-protein Related Cardiac Disease

2023-1-27-2

It is expected to include 40 patients with M-protein related cardiac disease. The treatment medication for enrolled patients must comply with the treatment regimen of Daratumumab + Bortezomib + Dexamethasone. All patients were given Dapagliflozin 10mg/day at the beginning of treatment (creatinine clearance rate greater than 20ml/min).

2024-03-15

2025-01-30

2025-12-31

Not yet recruiting

40

Inclusion Criteria: * M-protein related cardiac disease aged 18 and above (at least one of the following criteria is met): (1) Systemic amyloidosis of the affected heart; (2) Presence of M component and presence of arrhythmia, cardiac enzyme abnormalities, cardiac function abnormalities, and exclusion of other diagnosable cardiac diseases; * ECOG score 0-2; * Sign a written informed consent form. Exclusion Criteria: * Acute myocardial infarction; * Severe functional abnormalities in important organs such as lungs, liver, and kidneys (the carbon monoxide diffusion ability caused by chronic respiratory diseases is 50% lower than expected); * Major surgery, radiation therapy, infections requiring systemic antibiotic treatment, or other serious infections within 14 days after enrollment; * Individuals with mental illness, comprehension disorders, or other reasons that make it difficult to control themselves; * Pregnant or lactating women, as well as reproductive age patients who refuse to take appropriate contraceptive measures during this trial. If the patient is male, refuse to use adequate contraceptive methods or donate semen during the study period and within 3 months after receiving the last cycle of drug study; * Diagnosed or treated another malignant tumor within 2 years prior to enrollment; * Individuals with allergies to daratumumab, bortezomib, or dexamethasone components or more severe allergic constitutions; * HIV infected individuals (HIV antibody positive); * Active infection of hepatitis B and hepatitis C (hepatitis B B virus surface antigen positive and/or hepatitis B core antibody positive, hepatitis B virus DNA more than 1x103 copies/mL; hepatitis C virus RNA more than 1x103 copies/mL); * Participate in another clinical trial 30 days after the start of the trial and throughout the entire trial period; * The researcher determined that patients who are not suitable to participate in this study;

{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'COHORT', 'timePerspective': 'CROSS_SECTIONAL'}, 'bioSpec': {'retention': 'SAMPLES_WITHOUT_DNA', 'description': 'whole blood, urine, bone marrow'}, 'enrollmentInfo': {'count': 40, 'type': 'ESTIMATED'}}

2024-03-07