Clinical trial

Retrospective Investigation of the Effects of Different Uses of Lidocaine in the Prevention of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation

Name
DerinceTRH-EAtli-001
Description
Direct laryngoscopy and endotracheal intubation procedure stimulate the sympathetic nervous system, causing catecholamine release into the circulation and consequently hemodynamic changes.There are many studies showing that lidocaine is used intravenously to suppress the sympathetic response to laryngoscopy and endotracheal intubation. Nebulized lidocaine is often used to provide upper airway local anesthesia in fiberoptic guided awake intubation. In this study, the researchers aimed to compare the results of using intravenous lidocaine and nebulized lidocaine to suppress the hemodynamic response caused by laryngoscopy and endotracheal intubation retrospectively. Researchers' hypothesis; Nebulized lidocaine administration is more effective than intravenous lidocaine administration in suppressing the hemodynamic response due to laryngoscopy and endotracheal intubation in patients under general anesthesia.
Trial arms
Trial start
2023-12-01
Estimated PCD
2024-06-01
Trial end
2024-07-01
Status
Recruiting
Treatment
Nebulized Lidocaine
Before induction of anesthesia, 2% lidocaine + physiological saline was added to a nebulizer and inhaled for 3-5 minutes in the presence of 4-6 liters/minute of oxygen.
Arms:
Nebulized lidocaine
Iv Lidocaine
Intravenous %2 lidocaine was administered before induction of anesthesia.
Arms:
Intravenous lidocaine
Size
80
Primary endpoint
Heart Rate
Just before induction of anesthesia
Heart Rate
Immediately after induction of anesthesia
Heart Rate
5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation
Blood Pressure
Just before induction of anesthesia
Blood Pressure
Immediately after induction of anesthesia
Blood Pressure
5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation
Oxygen Saturation
Just before induction of anesthesia
Oxygen Saturation
Immediately after induction of anesthesia
Oxygen Saturation
5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation
Eligibility criteria
Inclusion Criteria: * Patients over the age of 18 and under the age of 80 who underwent surgery under general anesthesia Exclusion Criteria: * Patients under the age of 18 and over the age of 80 * Patients who are not operated under general anesthesia
Protocol
{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'COHORT', 'timePerspective': 'RETROSPECTIVE'}, 'enrollmentInfo': {'count': 80, 'type': 'ESTIMATED'}}
Updated at
2024-04-24

1 organization

1 product

1 indication

Product
Lidocaine
Indication
Lidocaine