Evaluation of Demineralized Dentin Matrix as a Scaffold for Revascularization in Immature Permanent Incisors: A Randomized Controlled Trial and an In -Vitro Study

AnishamsU ASU

Compare the clinical and radiographic outcomes of demineralized dentin matrix scaffold to blood clot scaffold in immature permanent incisors with non-vital pulps for one year (in vivo). Investigate the effect of demineralized dentin matrix (DDM) on dental pulp stem cells (DPSCs) (in vitro).

2022-11-01

2024-04-01

2024-07-01

Recruiting

30

Inclusion Criteria : patients clinical examination Must be include the following * Patients aged 7-13years at the time of enrolment. * Provision of informed consent by one parent or legal guardian. * At least the patents have one immature permanent anterior tooth diagnosed with irreversible pulpitis or pulp necrosis with or without periapical lesions. * Restorable teeth ,clinical crown should be enough to use rapper dam Compliant patient/parent. * Patients are not allergic to medicaments and antibiotics necessary to complete the procedure (ASA 1 or 2). * Radiologic evidence of open apices (Teeth are considered immature when a minimum of 0.8 mm apical foramen width is evident) * Exclusion Criteria: * the patients will excluded if one of the following criteria is present in the patients * Teeth with root fractures. * Presence of internal or external root resorptions. * Developmental anomalies of the root. * Presence of periapical radiolucency more than 10 mm. * Tooth with class III mobility.

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2023-08-23