Clinical trial
Investigating the Effects of Cannabidiol on Social Anxiety Disorder
Name
2206000688
Description
The purpose of this study is to test whether a single-dose of Epidiolex (cannabidiol) is associated with reduced psychological, physiological, and neuroimaging measures of anxiety in people diagnosed with social anxiety disorder (SAD).
Trial arms
Trial start
2023-12-01
Estimated PCD
2024-12-01
Trial end
2025-05-01
Status
Not yet recruiting
Phase
Early phase I
Treatment
Cannabidiol
Participants randomized to the cannabidiol arm will receive 3mL of Epidiolex (100mg cannabidiol/mL) in a single-dose.
Arms:
Cannabidiol
Other names:
Epidiolex
Placebo
Participants randomized to the placebo arm will receive 3mL of placebo (sesame seed oil) in a single dose.
Arms:
Placebo
Size
50
Primary endpoint
Change in Acute Subjective Anxiety
-180 minutes, -15 minutes, -5 minutes, +10 minutes, +20 minutes, +30 minutes
Eligibility criteria
Inclusion Criteria:
* Ability and willingness to provide written informed consent.
* Sufficiently fluent in English to participate in the trial.
* Between 18-55 years of age (inclusive).
* Right-hand dominant.
* Current medications are stable for past 30 days (no changes to dose or frequency).
* Negative result on pregnancy test (if female).
* Negative result on urine drug screening.
* Current diagnosis of social anxiety disorder (QuickSCID-5).
* Liebowitz Social Anxiety Scale (LSAS ≥ 60).
Exclusion Criteria:
* History of bipolar disorder, schizophrenia, psychosis, delusional disorders.
* History of eating disorder within past 6 months.
* History of any traumatic brain injury.
* Currently diagnosed with diabetes mellitus.
* Presence of severe medical illness that would prevent completion of study procedures.
* Presence of significant neurological illness or cognitive dysfunction (e.g.; seizures, dementia).
* History of substance use disorder within past 6 months (other than nicotine and caffeine).
* Use of any cannabis-containing products in past 30 days (CBD or THC).
* Use of beta-blockers or benzodiazepines in past 2 weeks.
* History of claustrophobia.
* Contraindications for MRI (e.g.; shrapnel).
* Presence of any other medical condition that, in the investigator's opinion, may interfere with the study procedures.
* Use of concomitant medication that has a strong interaction with CYP3A4 or CYP2C19 (as assessed through Lexicomp).
* History of liver disease.
* History of hypersensitivity to cannabinoids.
* History of hypersensitivity to sesame seed oil.
* Currently breastfeeding (if female).
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'OTHER', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 50, 'type': 'ESTIMATED'}}
Updated at
2023-09-28
1 organization
2 drugs
2 indications
Organization
Massachusetts Institute of TechnologyDrug
cannabidiolIndication
PhobiaIndication
SocialDrug
Varlilumab