Clinical trial

Genetic Studies of Early-onset Dementia

Name

AAAQ9793

Description

The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.

Trial arms

Trial start

2016-09-14

Estimated PCD

2028-04-30

Trial end

2028-04-30

Status

Recruiting

Treatment

Blood draw

Blood draw for identification of genetic variants associated with the development of memory problems

Arms:

Cognitively Healthy, Dementia/Alzheimer's Disease, Mild Cognitive Impairment

Neurocognitive testing

Brief memory test

Arms:

Cognitively Healthy, Dementia/Alzheimer's Disease, Mild Cognitive Impairment

Medical questionnaire

Collection of medical history

Arms:

Cognitively Healthy, Dementia/Alzheimer's Disease, Mild Cognitive Impairment

Size

1000

Primary endpoint

Genetic risk variants associated with early-onset dementia

2 years

Changes in blood biomarkers in early-onset dementia

2 years

Eligibility criteria

Inclusion criteria: * 18 years and older * Individuals diagnosed with dementia, their family members and unrelated healthy controls without dementia. Exclusion Criteria: -Individuals with competing diagnosis such as Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc., unless family members of a dementia affected individual

Protocol

{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'COHORT', 'timePerspective': 'PROSPECTIVE'}, 'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'Approximately 40ml of blood and/or saliva'}, 'enrollmentInfo': {'count': 1000, 'type': 'ESTIMATED'}}

Updated at

2024-04-09

1 organization

Organization

Columbia University