Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus

IIT-2022-0245

The purpose of this study is to analyze the effects of GLP-1RA on blood glucose, body weight, glucose and lipid metabolism and fat distribution in overweight/obese patients with type 2 diabetes mellitus.

2023-02-23

2025-02-23

2025-02-23

Recruiting

300

Inclusion Criteria: * Aged 18-65 years old * BMI≥24kg/㎡, or waist circumference: \> 85cm (for male) or \> 80cm (for female) * Has been diagnosed with type 2 diabetes mellitus * Good blood glucose control in recent three months: random blood sugar \< 14mmol/L and HbA1c 6-9% * Not received any drugs affecting glucose and lipid metabolism or weight loss surgery in the past one month Exclusion Criteria: * Abnormal weight gain caused by other endocrine diseases * Severe metabolic diseases, such as diabetic ketoacidosis, hypertonic hyperglycemia * Type 1 diabetes or other special types of diabetes * Used drugs affecting glycolipid metabolism in the past three months * Severe bleeding tendency that unable to complete venous blood collection * Patients with MRI contraindications * Severe renal insufficiency or severe liver insufficiency * Patients with advanced malignant tumors * Serious cardiovascular and cerebrovascular diseases * Rheumatic and immune diseases * Pregnant and lactating women

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 300, 'type': 'ESTIMATED'}}

2023-05-16