Clinical trial
MB001-067 A PROSPECTIVE, DOUBLE BLIND, PLACEBO CONTROLLED, PARALLEL GROUP, RANDOMIZED TRIAL OF EXTENDED RELEASE EXENATIDE VERSUS PLACEBO (COHORT A) AND A PROSPECTIVE, SINGLE GROUP, OPEN-LABEL, BLINDED OUTCOME TRIAL OF EXTENDED RELEASE EXENATIDE (COHORT B) IN DIABETIC PATIENTS WITH TYPE 4 CARDIORENAL SYNDROME (EXTEND-CRS TRIAL) AMENDMENT 3
Name
014-149
Description
Among adult individuals with type 2 diabetes mellitus and at risk for heart failure with impaired relaxation of the heart mildly reduced kidney filtration function (Type 4 cardiorenal syndrome) this trial will evaluate the quantitative impact of 38 weeks of treatment with exenatide extended-release injections versus placebo. on a cardiac biomarker blood test score, cardiac fibrosis seen on magnetic resonance scanning, cardiac strain identified by ultrasonography and strain rate imaging, and a kidney urine biomarker score.
Trial arms
Trial start
2015-11-01
Estimated PCD
2019-12-01
Trial end
2019-12-01
Status
Completed
Phase
Early phase I
Treatment
BYDUREON
Exenatide-extended release, Cohorts A and B
Arms:
Exenatide-extended release
Placebo
Cohort A only
Arms:
Placebo
Other names:
Matching placebo subcutaneous injection
Size
57
Primary endpoint
Galectin-3
38 weeks
ST2
38 weeks
NGAL
38 weeks
KIM-1
38 weeks
L-FABP
38 weeks
IL-18
38 weeks
Alpha GST
38 weeks
Troponin I
38 weeks
Pi GST
38 weeks
NAG
38 weeks
Cystatin-C
38 weeks
BNP
38 weeks
ACR
38 weeks
Eligibility criteria
Inclusion Criteria:
* Age ≥ 18
* Type 2 diabetes mellitus with hemoglobin A1C 6.6-9.9% with or without the use of insulin
* Estimated glomerular filtration rate (eGFR) between 50 and 90 ml/min/1.73 m2
Exclusion Criteria:
* Allergy or intolerance to gadolinium
* Implanted cardiac pacemaker, defibrillator, loop recorder, or other implanted metallic device
* Any other metallic implanted device that is a contra-indication to MRI scanning
* eGFR \< 50 ml/min/1.73 m2
* eGFR \> 90 ml/min/1.73 m2
* Patient has ever been treated with an approved or investigational GLP-1 receptor agonist e.g. BYETTA™ (exenatide), BYDUREON™ (Exenatide extended-release), VICTOZA™ (liraglutide), or taspoglutide
* Patient is enrolled in another experimental protocol which involves the use of an investigational drug or device, or an intervention that would interfere with the conduct of the trial.
* Disorders of iron metabolism
* Collagen vascular diseases
* Myocardial infarction
* Use of DDP4 inhibitors, and PPAR gamma agonists
* Pregnancy or planned pregnancy during the trial period
* Hemoglobin A1C of ≥ 10.0% or \<6.6%
* Fasting glucose ≥ 260 mg/dl
* Clinically significant abnormal baseline laboratories
* Morbid obesity or body girth that prohibits the ability to undergo echocardiography or MRI scanning with high-quality image results
* Renal transplantation
* Severe gastrointestinal, liver, or neurodegenerative disease
* Decompensated liver cirrhosis (Child-Pugh score \>7)
* New York Heart Association Class III or IV heart failure
* Patients have alanine aminotransaminase (ALT) greater than 5 times the upper limit of the reference range.
* Prior pancreatitis
* Personal or family history of medullary thyroid adenoma or carcinoma (MTC)
* Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
* History of severe hypoglycemia
* Prior bariatric surgery
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 57, 'type': 'ACTUAL'}}
Updated at
2023-05-17
1 organization
1 product
1 drug
3 indications
Organization
Baylor Research InstituteProduct
BYDUREONIndication
Type 2 Diabetes MellitusIndication
chronic kidney diseaseIndication
Left Ventricular Diastolic DysfunctionDrug
Varlilumab