An Open-Label, Five-Period Study in Healthy Subjects to Investigate the Relative Bioavailability of AZD5055 Film-Coated Tablet Versus AZD5055 Oral Suspension Formulation, the Absolute Oral Bioavailability of AZD5055 and to Evaluate the Effect of Food and an Acid Reducing Agent on the Pharmacokinetics of AZD5055.

D8960C00002

This study will estimate the relative bioavailability of AZD5055 film-coated tablet as compared to AZD5055 oral suspension. The study will also assess the absolute bioavailabilty of AZD5055 and the effect of food and an acid reducing agent, rabeprazole, on the PK of AZD5055 film-coated tablets when given with food (fed state) or without food (fasted state).

2022-11-04

2023-02-09

2023-02-09

Completed

Early phase I

21

Inclusion Criteria: 1. Healthy male and female (of non-childbearing potential) subjects aged 18 to 55 years. 2. Female subjects must have a negative pregnancy test. 3. Male subjects must adhere to the contraception methods as per Protocol. 4. Have a BMI between 18 and 30 kg/m2 inclusive. Exclusion Criteria: 1. History of any clinically significant disease or disorder which may either put the subject at risk because of participation in the study or influence the results or the subject's ability to participate in the study. 2. Ongoing acute Gastrointestinal (GI), hepatic, or renal disease, a history of chronic GI, hepatic, or renal disease, pancreatic disease, diabetes mellitus, or any condition known to interfere with absorption, distribution, metabolism, or excretion of drugs. 3. Any clinically significant illness, medical/surgical procedure, or trauma within 4 weeks of the first administration of study drug. 4. Ongoing acquired or inherited immunodeficiency disorders, including but not limited to Human Immunodeficiency Virus (HIV) or common variable immunodeficiency, or the subject is taking immune replacement therapy. 5. Individuals with chronic infections or who are at increased risk of infection. 6. History of cancer within the last 10 years (20 years for breast cancer). Any history of lymphoma is not allowed. 7. History of osteoporosis, osteomalacia, Paget's disease of the bone, thyrotoxicosis, rheumatoid arthritis, Cushing's disease, or a pathological fracture. 8. History of a traumatic fracture within 6 months of the Screening Visit. 9. Any clinically significant abnormalities in clinical chemistry, hematology, or urinalysis. 10. Abnormal vital signs. Any clinically important abnormalities in rhythm, conduction, or morphology of the resting ECG and any clinically important abnormalities in the 12-lead ECG. 11. Untreated tuberculosis (TB) or a positive result for the Interferon gamma release assay (IGRA) (ie, QuantiFERON TB Gold). 12. Any positive result at Screening for serum hepatitis B surface antigen, hepatitis B core antibody, or hepatitis C antibody, and HIV antibody. 13. History of severe COVID-19 infection requiring hospitalization within the last 12 months prior to Screening, or clinical history compatible with Long COVID-19 (symptoms beyond 12 weeks of acute infection). 14. Confirmed COVID-19 infection during at admission. 15. Has received live or live attenuated vaccine in the 30 days prior to dosing, the first dose of COVID- vaccine within 30 days prior to randomization, or a COVID-19 vaccine second or booster vaccination within 10 days of Screening. 16. Known or suspected history of drug abuse. 17. History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity. 18. Current smokers or use of any tobacco in any other form. 19. Known or suspected history of alcohol or drug abuse or excessive intake of alcohol. 20. Use of drugs with enzyme-inducing properties such as St John's Wort.

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 21, 'type': 'ACTUAL'}}

2024-03-04