Optic IconOptic Logo
|
SearchCollectionsBenchmarks
Clinical trial

The Effect of Sildenafil Citrate on the Endometrial Thickness and Pregnancy Rates of Frozen Embryo Transfer Cycles

ID
Name
frozen embryo tansfer 1
Description
to investigate the value of adding sildenafil citrate during endometrial preparation in patients undergoing frozen-thawed embryo transfer and its effect on endometrial thickness and pregnancy rates.
Trial arms
Trial start
2023-06-30
Estimated PCD
2023-09-30
Trial end
2023-09-30
Status
Recruiting
Phase
Early phase I
Treatment
Sildenafil Citrate
a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5),
Arms:
Sildenafil
Other names:
respatio, Viagra
estradiol
estradiol in form of Cycloprogynova white pills starting dose is one pill t.i.d may be increased to two pills t.i.d according to endometrial thickness in day 9 measured by vaginal ultrasound.
Arms:
Sildenafil, control
Other names:
Cycloprogynova
Size
110
Primary endpoint
endometrial thickness
10 to 16 days from start of cycle
Eligibility criteria
Inclusion Criteria: 1. Age under 40 years 2. Subject has high quality frozen embryos Exclusion Criteria: 1-A history of endocrine diseases. 2. A history of any previous surgery that could compromise the integrity of endometrium. 3. Cardiovascular, renal and liver diseases. 4. Hypotension (blood pressure less than 90/50). 5. A history of stroke or myocardial infarction. 6. A history of previous implantation failure.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2', 'PHASE3'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 110, 'type': 'ESTIMATED'}}
Updated at
2023-07-19

1 organization

2 products

1 indication

Organization
Beni-Suef University
Product
Sildenafil Citrate
Indication
In vitro fertilization (IVF)
Product
estradiol