Clinical trial

Dexmedetomidine Versus Magnesium Sulfate in Controlled Hypotension During Rhinoplasty Surgeries

Name
Sameh
Description
General anesthesia organizes the best option for controlled blood pressure during rhinoplasty surgery. The primary agent applied in controlling hypotension should have particular unique characteristics. The dexmedetomidine central and peripheral sympatholytic performance is usually indicated by low blood pressure and low heart rate. magnesium sulfate is among the best agents used.
Trial arms
Trial start
2022-01-01
Estimated PCD
2023-04-01
Trial end
2023-05-01
Status
Completed
Phase
Early phase I
Treatment
Dexmedetomidine
Group 1 received dexmedetomidine
Arms:
group 1
Other names:
magnesium sulfate
Magnesium sulfate
the group 2 received magnesium sulfate
Arms:
group 2
Size
56
Primary endpoint
The primary outcome was to determine the bleeding score
24 hours postoperative period
Eligibility criteria
Inclusion Criteria: 1. 18-60 years old 2. ASA (American Society of Anesthesiologists) grading I and II 3. patients undergo rhinoplasty surgery under general anesthesia Exclusion Criteria: 1. The pregnant ladies 2. patients suffering from hypertension ischemic heart diseases renal insufficiency, neuromuscular diseases, hepatic impairment 3. cerebrovascular inadequacy and diabetic neuropathy, coagulopathies, 4. patients taking antiplatelets 5. Refused study, 6. patients of age \< 18 or \> 60 were unauthorized from the study.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'interventionModelDescription': '56 patients got enrolled and then divided into two groups. Group 1 received dexmedetomidine (n=28), while the group 2 received magnesium sulfate (n=28). MAP, as well as heart rate, were recorded. Surgeon satisfaction was approximated for the surgical field quality.', 'primaryPurpose': 'PREVENTION', 'maskingInfo': {'masking': 'SINGLE', 'maskingDescription': '56 patients got enrolled and then divided into two groups. Group 1 received dexmedetomidine (n=28), while the group 2 received magnesium sulfate (n=28). MAP, as well as heart rate, were recorded. Surgeon satisfaction was approximated for the surgical field quality.', 'whoMasked': ['INVESTIGATOR']}}, 'enrollmentInfo': {'count': 56, 'type': 'ACTUAL'}}
Updated at
2023-05-31

1 organization

2 products

1 indication

Organization
Mohamed