Clinical trial
A Phase 2 ,Safety and Efficacy Study of Jaktinib Hydrochloride Tablets for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease.
Name
ZGJAK013
Description
This is an single-arm, Phase II multi-center study. The purpose of this study is to assess the efficacy and safety of Jaktinib in subjects with Grades II to IV steroid-refractory acute graft-versus-host disease.
Trial arms
Trial start
2024-12-01
Estimated PCD
2025-06-01
Trial end
2025-07-01
Status
Not yet recruiting
Phase
Early phase I
Treatment
Jaktinib Hydrochloride Tablets
Oral on an empty stomach
Arms:
Jaktinib treatment
Other names:
Jaktinib
Size
60
Primary endpoint
Overall Response Rate (ORR) at Day 28
Day 28
Eligibility criteria
Inclusion Criteria:
* Have undergone first allogeneic hematopoietic stem cell transplantation (allo-HSCT) from any donor source using bone marrow, peripheral blood stem cells, or cord blood for hematologic malignancies. Recipients of nonmyeloablative and myeloablative conditioning regimens are eligible.
* Clinically suspected Grades II to IV acute GVHD according to NCCN guidelines 2020 V2.0, occurring after allo-HSCT with any conditioning regimen and any anti-GVHD prophylactic program.
* Subjects with steroid-refractory acute GVHD, defined as any of the following:
Subjects with progressive GVHD (ie, increase in stage in any organ system or any new organ involvement) after 3-5 days of primary treatment with methylprednisolone ≥ 2 mg/kg per day (or equivalent) ± Calcineurin inhibitors(CNI);Subjects with GVHD that has not improved (ie, decrease in stage in at least 1 involved organ system) after 5-7 days of primary treatment with methylprednisolone ≥ 2 mg/kg per day (or equivalent) ± Calcineurin inhibitors(CNI);Subjects who Corticosteroid dependence(ie, begin corticosteroids at 2.0 mg/kg per day, demonstrate response, but progress before decrease from the initial starting dose of corticosteroids is achieved).
* ECOG: 0-2;
* Life expectancy \> 4 weeks;
* Ability for oral drug intake;
* Willingness to comply with all study visits and procedures.
Exclusion Criteria:
* Has received more than 2 allo-HSCT.
* Acute GvHD occurring after non-scheduled donor leukocyte infusion (DLI) administered.
* Has received more than 1 systemic treatment in addition to corticosteroids for acute GVHD.
* Presence of an active uncontrolled infection.
* Serum creatinine \> 1.5 ULN or creatinine clearance \< 30 mL/min calculated by Cockcroft-Gault equation.
* Known allergies, hypersensitivity, or intolerance to any of the study medications, excipients, or similar compounds.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 60, 'type': 'ESTIMATED'}}
Updated at
2024-03-06
1 organization
1 product
1 indication
Organization
Suzhou Zelgen BiopharmaceuticalsProduct
JaktinibIndication
Acute Graft-Versus-Host Disease