Attenuation Of Hemodynamic Response To Laryngoscopy. Role Of Dexmedetomidine. A Dose Finding Study

SindhInstitute

Two doses of Dexmedetomidine (0.5 µ/kg and 0.75 µ/kg) will be used to attenuate the stress response to laryngoscopy in American Society of Anesthesiology, physical class I patients which will be compared with the placebo-controlled group.

2021-08-23

2021-12-13

2021-12-13

Completed

Early phase I

105

Inclusion Criteria: * Age between 18 to 55 years * ASA I or II patients undergoing surgery under general anaesthesia with endotracheal intubation. * Patients with Mallampati class I or II. Exclusion Criteria: * ASA III \& IV patients * Anticipated or unanticipated difficult intubations which requires more than 15 seconds or more than one attempt. * Patients with Mallampati class III, IV or with loose teeth. * Patients with inotropes infusion. * Patients with known allergy to any anaesthetic agents * Patients with a heart rate of 60 beats/min or less * Patients with known hypertension, incidental finding of hypertension while on operating table, diabetes, ischemic heart disease or peripheral vascular disease. * Pregnant and lactating mothers.

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 105, 'type': 'ACTUAL'}}

2023-06-18