Clinical trial

Immediate Versus Postponed Freeze-all Embryo Transfer in Hyperresponders, A Multicenter Randomised Controlled Trial

Name

Delay-ET-RCT

Description

This is a multicenter, randomised controlled trial. The investigators plan to randomise 836 participants to the immediate FET or the postponed FET from the day of oocyte retrieval to the last day of that menstrual cycle in a 1:1 rate. Primary outcome will be the live birth rate after the embryo transfer.

Trial arms

Trial start

2022-08-30

Estimated PCD

2023-12-01

Trial end

2024-12-01

Status

Recruiting

Treatment

the timing of embryo transfer in freeze-all cycles

Immediate FET group Freeze-all embryo transfer will be carried out in the menstrual cycle immediately following oocyte retrieval. Postponed FET group Freeze-all embryo transfer will be carried out during the second menstrual cycle to 6 months after oocyte retrieval.

Arms:

Immediate FET group, Postponed FET group

Size

836

Primary endpoint

Live birth after the first embryo transfer

At least 22 months gestation after the first embryo transfer cycle

Eligibility criteria

Inclusion Criteria: * Women aged 20 to 42 years old; * Written informed consent; * Women scheduled for freeze-all embryo transfer; * Women with the number of oocyte collected higher than 15. Exclusion Criteria: * Women with a history of at lease three failed transfer cycles; * Women with an endometrial thickness less than 7 mm on the triggering day; * Severe uterine malformations.

Protocol

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 836, 'type': 'ESTIMATED'}}

Updated at

2023-05-31

1 organization

1 product

1 indication

Organization

Peking University Third Hospital

Product

Embryo Transfer Timing

Indication

In vitro fertilization (IVF)