Clinical trial
Safety and Efficacy of Pre-incisional Intravenous Ibuprofen to Reduce Postoperative Pain and Opioid Dependence After Posterior Cervical or Lumbar Instrumented Spine Surgery
Name
13BN033
Description
A prospective, randomized, placebo controlled, double-blinded study at a single institution.
Trial arms
Trial start
2015-03-01
Estimated PCD
2017-06-01
Trial end
2017-07-17
Status
Terminated
Phase
Early phase I
Treatment
Ibuprofen
Arms:
Intravenous (IV) ibuprofen
Other names:
Caldolor
normal saline
Arms:
Intravenous (IV) normal saline
Other names:
NS
Size
6
Primary endpoint
Change in pain level
pre-operative, 1-3 weeks post-operative, 6 months post-operative
Change in overall health/function
pre-operative, 1-3 weeks post-operative, 6 months post-operative
Fusion rates
6 month post-operative
Eligibility criteria
Inclusion Criteria:
* Patients older than 18 years of age
* Able to give consent
* Diagnosed with spondylosis, stenosis, and/or instability of the cervical spine
* Diagnosed with spondylosis, stenosis, and/or instability of the lumbar spine
* Require a posterior decompression with internal fixation
* Likely to complete the trial
Exclusion Criteria:
* Patients with previous surgery at the treated spine segment
* Women who are pregnant or plan to become pregnant during the study period Renal/liver disease
* Anemia; coagulopathy
* Thrombocytopenia (\<30,000)
* Coronary artery disease
* Previous coronary artery bypass graft (CABG)
* Patients taking Coumadin, Plavix, Lithium, or ACE-inhibitors plus Lasix; non-steroidal anti-inflammatory drug (NSAID) hypersensitivity
* Gastric ulcers
* Recent stroke
* Traumatic brain injury, or intracranial surgery
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 6, 'type': 'ACTUAL'}}
Updated at
2024-04-19
1 organization
1 product
2 indications
Organization
St. Joseph's Hospital and Medical CenterProduct
IbuprofenIndication
Cervical SpondylosisIndication
Lumbar Spondylosis