Application of Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation

Islamic Azad University

Aging is a natural and complex process. The effect of environmental factors, genetics on the body eventually leads to damage in different ways. Exosomes are present in almost all body fluids, such as synovial fluid and blood. Exosomes and microvesicles are very efficient mediators of cell-to-cell communication by transferring their specific cargo to recipient cells; for example, exosomes are involved in the delivery of genetic materials, causing epigenetic modifications in the target cells .The applications of MSC-derived exosomes have more effect in cutaneous regeneration by collagen stimulation.The basic biology of exosomes indicates that MSC-exosomes may contain MSC-specific components to exert specific effects on recipient cells, which are somewhat equivalent to the regenerative effects of MSCs. This study aims to slow down the aging process of the skin by using exosome.

2022-02-01

2023-07-29

2023-08-30

Recruiting

Early phase I

20

Inclusion Criteria: * females * Ages 35-65 * Patients of all racial and ethnic origins * Patients of all undergoing facial rejuvenation Exclusion Criteria: * Female patients in pregnancy or menstrual period * Patients undergoing facial rejuvenation using other methods including Botox injections, chemical peels, face lifts and others * Patients using blood thinners, aspirin and hormone, that cannot be stopped * Patients suffering with severe organic disease, such as coronary heart disease, hypertension, diabetes, lung dysfunction and so on * Patients suffering with mental disease, and acute or chronic infectious diseases

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2023-04-14