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Clinical trial

Prevalence of of Apical Periodontal in Patients Chronic Kidney Disease & Its Association With Markers of Kidney Disease.

ID
Name
Dr. Jyoti Lamba
Description
This investigation is aimed to assess the prevalence and severity of apical periodontitis (AP) in different stages of CKD patients and its impact on the systemic (nutritional and inflammatory) markers was compared to healthy individuals.
Trial arms
Trial start
2021-12-01
Estimated PCD
2022-12-31
Trial end
2022-12-31
Status
Completed
Treatment
levels of CKD markers, Oral health status, apical periodontitis
To observe levels of CKD markers :Levels of serum keratinise ,urea, eGFR, and assessment of Oral health status, apical periodontitis
Arms:
Group-A CKD patients
systemic inflammatory marker, Oral health status, apical periodontitis
estimation of hs-CRP levels, and assessment of Oral health status, apical periodontitis
Arms:
Group-B Healthy individuals
Size
210
Primary endpoint
Periapical Index(PAI)
1 year
eGFR
1 year
serum creatinine
1 year
hs-CRP
1 year
Blood urea
1 year
Eligibility criteria
Inclusion Criteria: * Known patient of CKD Stages 1,2,3,4 \& 5 with estimated glomerular filtration rate \[eGFR; MDRD\] with mature permanent teeth. * \> 18 years * \> 8 natural teeth. * Complete medical \& dental history including panoramic radiographs of maxilla \& mandible Exclusion Criteria: * Patients having systemic disorders other than CKD (eg HIV, Diabetes mellitus, Coronary heart disease, history of secondary hyperparathyroidism). * Pregnancy, lactation \& contraceptives. * Systemic conditions that contra indicates dental treatment. * Use of antibiotics \& anti-inflammatory in last 3 months * Need for antibiotic prophylaxis. * Hepatitis C and B virus. * Patients on steroids.
Protocol
{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'OTHER', 'timePerspective': 'CROSS_SECTIONAL'}, 'bioSpec': {'retention': 'SAMPLES_WITHOUT_DNA', 'description': 'Blood analysis for CRP, Serum ferritin, Albumin, Creatinine \\& Urea'}, 'enrollmentInfo': {'count': 210, 'type': 'ACTUAL'}}
Updated at
2023-04-19

1 organization

2 products

2 indications

Organization
Postgraduate Institute of Dental Sciences Rohtak
Product
CKD markers
Indication
Chronic Kidney Disease
Indication
Periapical Lesions
Product
Systemic inflammatory marker