Study on the Application of Hyperspectral Imaging Technique in the Treatment of TAC

TAC-IMN-HSI

We propose hyperspectral imaging analysis as a method to identify the efficacy of hormone-tacrolimus therapy for PMN, and to classify sensitive and insensitive patients treated with hormone-tacrolimus regimen. A variety of machine learning models were used to prove that hyperspectral imaging technology could assist patients in selecting the optimal treatment plan, and further explore the predictive indicators of PMN treatment effect.

2023-04-25

2023-07-20

2023-12-30

Not yet recruiting

40

Inclusion Criteria: * Over 18 years old; * Patients with idiopathic membranous nephropathy confirmed by renal biopsy; * Had not received hormone and/or immunosuppressive therapy before renal biopsy; * Complete clinical data, all signed the "Admission Certificate of Qianfoshan Hospital of Shandong Province", and agreed to use relevant medical information, biological specimen examination and examination results for scientific research. Exclusion Criteria: * There are factors causing secondary membranous nephropathy, such as immune diseases (systemic lupus erythematosus), tumors/infections (viral hepatitis), drugs or poisons, etc; * Severe infection: fever, cough and expectoration, sore throat, abdominal pain, diarrhea, carbuncle and furuncle and other clinical manifestations of skin and soft tissue infection, blood routine white blood cell count beyond the normal range (10×109/L); * Severe cardiovascular disease: including chronic heart failure grade 3 or above and various arrhythmias; * Infectious diseases: active hepatitis, AIDS, syphilis, etc. ; * Tumor evidence: it has been found that there is a certain tumor or clinical manifestations, tumor markers, etc.,suggesting the possibility of tumor; * Patients with follow-up time less than 6 months, incomplete data or missed diagnosis.

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2023-04-04