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Clinical trial

The Effect of Intercostal Nerve Block With Dexamethasone and Ropivacaine on Rebound Pain After Thoracoscopic Surgery: a Randomized, Double-blind, Controlled Study

ID
Name
20230411
Description
Regional nerve block is one of the commonly used methods for postoperative analgesia after thoracoscopic surgery. Recent studies have found that rebound pain may occur after regional block, which is defined as acute postoperative pain that occurs after the resolution of sensory block related to regional anesthesia, and seriously affects the quality of postoperative recovery of patients. There is evidence that rebound tenderness is associated with local anesthetic toxicity and proinflammatory effects. The aim of this study was to investigate the effect of dexamethasone on rebound pain after a single intercostal nerve block in patients undergoing thoracoscopic surgery.
Trial arms
Trial start
2023-05-01
Estimated PCD
2025-05-05
Trial end
2025-08-06
Status
Not yet recruiting
Treatment
Dexamethasone 8mg+0.375% ropivacaine
Ultrasound-guided intercostal nerve block was performed on the surgical side, and 3 to 5ml of a mixture of 0.375% ropivacaine and 8 mg dexamethasone was injected at each point
Arms:
group dexamethasone
0.375% ropivacaine
Ultrasound-guided intercostal nerve block was performed on the surgical side, and 3 to 5ml 0.375% ropivacaine was injected at each point
Arms:
group control
Size
260
Primary endpoint
The incidence of rebound pain after the disappearance of nerve block effect
8 hours after the nerve block
Eligibility criteria
Inclusion Criteria: * Patients scheduled for elective thoracoscopic surgery Age \> 18 years old ASA ⅰ-ⅲ Informed consent was signed Exclusion Criteria: * Patients with aoagulation disorders Patients with allergy to local anesthetics Patients with severe cardiopulmonary diseases Patients had systemic steroid use Patients with chronic pain Patients with uncontrolled diabetes and mental disorders History of drug abuse; Body Mass Index more than 35 kg.m-2 Pregnant or breastfeeding woman.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 260, 'type': 'ESTIMATED'}}
Updated at
2023-04-24

1 organization

2 products

4 indications

Organization
Beijing Tiantan Hospital
Product
Dexamethasone
Indication
Rebound Pain
Indication
Dexamethasone
Indication
Intercoastal Nerve Block
Indication
Thoracoscopic Surgery
Product
Ropivacaine