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Clinical trial

Bariatric Surgery and Pharmacokinetics Enalapril: BAR-MEDS Enalapril

ID
Name
2016/1145j
Description
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on enalapril are investigated.
Trial arms
Trial start
2016-11-02
Estimated PCD
2026-10-01
Trial end
2026-10-01
Status
Recruiting
Treatment
Enalapril
Patients are tested for their normal prescription enalapril medication
Other names:
Renitec
Size
12
Primary endpoint
Enalapril concentration in blood serum (area under curve (AUC))
From baseline to 1 year postoperatively
Eligibility criteria
Inclusion Criteria: * Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway * Being a Norwegian citizen Exclusion Criteria: * Having previously undergone resections in the GI-tract
Protocol
{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'CASE_ONLY', 'timePerspective': 'PROSPECTIVE'}, 'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'Blood'}, 'enrollmentInfo': {'count': 12, 'type': 'ESTIMATED'}}
Updated at
2023-03-27

1 organization

1 product

2 indications

Organization
Norwegian University of Science and Technology
Product
Enalapril
Indication
Obesity
Indication
Morbid