Clinical trial

Comparison Of The Outcome Of Treatment of Microneedling With Autologous Platelet- Rich -Plasma Versus Microneedling With Topical Insulin In The Treatment Of Post Acne Atrophic Scars.

Name

NO.F.2-81/2022-GENL/252/JPMC

Description

Microneedling with topical INSULIN is a simple, effective tool for building body's new collagen layers and thus an alternative to all erosive techniques such as lasers, peels. The skin responds to fine punctures with the release of growth factors. 8 It is a safe procedure that can be performed in the office without complications, with a good cost-benefit because it is economically viable without any effect on patient's daily activities. 9

Trial arms

Trial start

2022-08-01

Estimated PCD

2022-12-01

Trial end

2023-02-01

Status

Completed

Phase

Early phase I

Treatment

PRP( platelet rich plasma) and Insulin human

Microneedling with autologus PRP reduces inflammationin acne scars. Insulin human is a new topical drug which is used nowadays for acne scars as it is more effective in producing collagen formation as well as new blood vessel formation

Arms:

GROUP A Microneedling with PRP(platelete rich plasma), GROUP B Microneedling with topical INSULIN

Size

Primary endpoint

Efficacy of Topical Insulin R with microneedling versus Platelets rich plasma in atrophic acne scars

Efficacy will be assesed upto 4 months.

Eligibility criteria

Inclusion Criteria: * postacne atrophic scars ≥ 2 on Goodman and Baron's acne scar-grading system * Either gender. * Age 20-50 years. Exclusion Criteria: * lactation and pregnancy * skin cancers and infection * photosensitivity like SLE ,XP * use of RETINOIDS in last 6 months.

Protocol

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 50, 'type': 'ACTUAL'}}

Updated at

2023-08-21

1 organization

1 product

1 indication

Organization

Jinnah Postgraduate Medical Centre

Product

PRP and Insulin human

Indication

Atrophic Acne Scars