Clinical trial
NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury (NACAM) Trial
Name
1620125
Description
A Randomized, Double-blind, placebo-controlled Trial to Evaluate the Efficacy of Oral Nam for the Prevention of Acute Kidney Injury in Patients Undergoing On-Pump Cardiac Surgery
Trial arms
Trial start
2021-09-13
Estimated PCD
2025-04-30
Trial end
2025-06-30
Status
Recruiting
Phase
Early phase I
Treatment
Niacinamide
Niacinamide 3 grams on the day of surgery and post-surgical days one and two
Arms:
Oral niacinamide
Placebo
Matched placebo on the day of surgery and post-surgical days one and two
Arms:
Matched placebo
Size
304
Primary endpoint
Troponin T AUC
From baseline to three days after surgery
Eligibility criteria
Inclusion Criteria
* Informed consent before any study-related activities.
* Men or women \>18 years of age who are scheduled for non-emergent cardiac surgery procedures requiring CPB and are at increased risk for surgery-related adverse cardiovascular outcomes.
Procedures include:
* CABG
* Aortic, mitral, tricuspid, or pulmonic valve replacement or repair
* CABG with aortic, mitral, tricuspid, and/or pulmonic valve replacement
Risk factors for surgery related to adverse cardiovascular outcomes include one or more of the following:
* Valve surgery
* eGFR \< 45 ml/min/1.73m2
* Documented LVEF ≤ 35% within six months before surgery
* Documented history of heart failure
* Insulin-requiring diabetes
* Non-insulin-requiring diabetes and the presence of ≥+2 proteinuria on urinalysis (or equivalent on urine protein-to-creatinine ratio or urine albumin-to-creatinine ratio)
* Preoperative anemia (hemoglobin \<11g/dl for men and women)
* History of prior CABG
* Age ≥65
Exclusion Criteria
* Preexisting AKI within seven days before surgery as defined by KDIGO stage ≥1 (serum creatinine-based)
* Kidney transplant status
* Off-pump cardiac surgery
* ESRD
* Emergent cardiac surgery
* Pregnancy
* Patient enrolled in competing research studies that may affect outcomes
* Patients held in an institution by legal or official order
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'PREVENTION', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 304, 'type': 'ESTIMATED'}}
Updated at
2023-07-18
1 organization
1 product
1 drug
3 indications
Organization
Kaiser PermanenteProduct
NiacinamideIndication
Ischemia Reperfusion InjuryIndication
Myocardial InjuryIndication
Acute Kidney InjuryDrug
Varlilumab