Hyaluronic Acid vs Platelet Rich Plasma: Prospective Double-blind Randomized Controlled Trial Comparing Clinical Outcomes and the Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis

10012103-AM02

In this, prospective, double-blind study, patients with mild to moderate symptomatic knee osteoarthritis will be randomized to receive either a series of leukocyte poor, platelet-rich plasma or hyaluronic acid injections under ultrasound guidance. Clinical data in the form of subjective outcome measures will be collected pre-treatment and at four time intervals across a 1-year period. Synovial fluid will also collected for analysis of pro- and anti-inflammatory markers pre-treatment, and at 12 and 24 weeks.

2011-08-01

2015-04-01

2015-04-01

Completed

111

Inclusion Criteria: * 18-80 years old * Mild to moderate unilateral, symptomatic osteoarthritis of the knee * No recent (within 3 months) intra-articular intervention to the affected knee Exclusion Criteria: * Knee instability * Varus/Valgus alignment \>5 degrees * Bilateral knee osteoarthritis * Systemic inflammatory arthropathy * Known history of anemia, coagulopathy, or present use of blood thinners

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 111, 'type': 'ACTUAL'}}

2023-03-14