Clinical trial
Multidimensional Integrated Assessment of Neurological and Immunological Patterns to Test the Efficacy and Response to Ozanimod in Multiple Sclerosis.
Name
EUDRACT 2021-005860-24
Description
This is a prospective interventional study with a 12-month follow-up of patients diagnosed with Multiple Sclerosis. Enrollment includes patients for whom Ozanimod will be prescribed based on regular clinical practice. It is proposed to integrate the measurements obtained using multiple instruments, with the aim of analyzing the immunological landscape, connectivity networks and anatomical traits of neurodegeneration.
Patients will return for imaging and noninvasive electrophysiological studies 3, 6, and 12 months after initiation of therapy. On the same day, blood samples will be taken and immunological and biochemical tests will be performed.
Trial arms
Trial start
2023-01-31
Estimated PCD
2025-01-31
Trial end
2025-01-31
Status
Recruiting
Phase
Early phase I
Treatment
Ozanimod Oral Capsule
We propose to integrate measurements obtained using multiple tools. Patients will undergo MRI and hdEEG procedures, and blood samples will be obtained for the immunological and biochemical studies on the same day. The study of the immune system's status will include an extensive immunophenotypic analysis, a functional characterization following ex vivo stimulation of innate immune cells, and the measurement of soluble products in the serum, such as cytokines. Cellular traits of interest include the absolute numbers and relative proportions of specific cell subsets, transcriptional states, secretory functions, proliferative capacity or cytolytic potential. Specifically, the following antibody combination will constitute the core of the immunophenotypic analysis: HLADR CD11c, CD38, CD14, CD123, lineage (CD3, CD56, CD19).
Arms:
Patient
Other names:
Zeposia
Size
30
Primary endpoint
verify the therapeutical activity of Ozanimod on the inflammatory mediated neurodegeneration.
12 months
Eligibility criteria
Inclusion Criteria:
* 1) Diagnosis of MS accordingly to 2017 revised McDonald criteria; 2) Patients candidate to receive Ozanimod therapy (disease characteristics, EDSS, age, lifestyle, disease progression, etc.); 3) Age between 18 and 45 years; 4) EDSS score from 0 to 4; 5) Signature and date of written ICF prior to entering the study;
Exclusion Criteria:
* The presence of any of the following will exclude a patient from study enrolment:
1. Ongoing immunomodulatory or immunosuppressive treatment;
2. Other autoimmune comorbidities (i.e. antiphospolipid syndrome);
3. Treatment with steroids in the last 30 days before enrollment;
4. Acute inflammatory status not MS related (i.e. bacterial or viral infections) in the previous 30 days;
5. Patients unable to read and understand the documents of the study.
6. Participation in any interventional clinical trials or compassionate use programs
7. Contraindications and "not-recommendations" reported in SmP
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 30, 'type': 'ESTIMATED'}}
Updated at
2023-03-21
1 organization
Organization
IRCCS Fondazione Santa Lucia