Clinical trial

The Impact of Estrogen Administration Duration on Live Birth Rates in Hormonally Prepared Frozen Embryo Transfer Cycles: A Prospective Controlled Study

Name

498496942

Description

This prospective controlled study aimed to investigate the effect of the duration of estrogen (E2) administration prior to progesterone (P) initiation on live birth rates (LBR) in frozen embryo transfer (FET) cycles. The study was conducted at a single tertiary-care in vitro fertilization (IVF) center and included 486 patients undergoing high-quality frozen blastocyst transfer in a hormone replacement therapy (HRT) cycle. Patients scheduled for E2 therapy were administered either 5-7, 8-10, or 11-13 days of treatment, depending on their presentation day. After the E2-only phase, if the endometrial thickness was above 7mm, P was initiated (daily 300mg of vaginal micronized P tablets), and FET was performed on the 6th day of P treatment. The primary outcome measure was LBR.

Trial arms

Trial start

2020-01-01

Estimated PCD

2021-12-31

Trial end

2023-05-01

Status

Completed

Treatment

micronized E2 at a daily dose of 4-6mg,

Arms:

11-13 days E2 therapy, 5-7 days E2 therapy, 8-10 days E2 therapy

Size

420

Primary endpoint

live birth rate

2 years

Eligibility criteria

Inclusion Criteria: * Exogenous hormone preparation of the endometrial lining * High embryo quality ((≥2BB) according to Alpha criteria * Embryo transfer at the blastocyst stage Exclusion Criteria: * - Patients whose treatments were canceled for any reason before the embryo transfer procedure * Patients who underwent embryo transfer in the cleavage stage * Presence of low-quality (\<2BB) blastocysts * \>15% loss of viability of the embryo during embryo thawing,

Protocol

{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'COHORT', 'timePerspective': 'PROSPECTIVE'}, 'enrollmentInfo': {'count': 420, 'type': 'ACTUAL'}}

Updated at

2023-05-22

1 organization

1 product

1 indication

Organization

Akdeniz University

Product

Indication

Estrogen Administration Duration