Clinical trial
A Randomised Controlled Trial of N-acetylcysteine for the Management of Alcohol Use Disorder
Name
X21-0342
Description
To explore the effectiveness of n-acetylcysteine in improving treatment outcomes for alcohol use disorder in a double-blind randomised placebo-controlled trial.
Trial arms
Trial start
2023-02-16
Estimated PCD
2025-11-01
Trial end
2026-11-01
Status
Recruiting
Phase
Early phase I
Treatment
N-acetyl cysteine
2400mg/day
Arms:
N-acetyl Cysteine
Other names:
NAC
Placebo
Matched placebo
Arms:
Placebo
Size
280
Primary endpoint
Heavy Drinking Days
24 weeks
Eligibility criteria
Inclusion Criteria:
* Alcohol Use Disorder according to the DSM-V criteria
* A desire to reduce or stop drinking
* Consumed at least 21 standard drinks per week or 2 heavy drinking days per week (HDD: ≥ 5 standard drinks/day for men; ≥4 for women) in the month prior to screening
* Adequate cognition and English language skills to give valid consent and complete research interviews
* Stable housing
* Willingness to give written informed consent
Exclusion Criteria:
* Pregnancy or lactation (women will be advised to use reliable contraception during the trial and a pregnancy test will be performed were necessary)
* Concurrent use of any psychotropic medication other than antidepressants (provided these are taken at stable doses for at least two months)
* Any substance dependence other than nicotine
* Clinically unstable systemic medical (e.g. cancer, end stage liver disease: e.g. MELD score ≥ 10) or psychiatric disorder (e.g. active psychosis, borderline personality disorder, active suicide risk: e.g. MADRAS item 10 score of 6) that precludes trial participation
* Concurrent use of selenium, vitamin D or other anti-oxidants
* Any alcohol pharmacotherapy within the past month
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'QUADRUPLE', 'maskingDescription': 'Double-blind design', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 280, 'type': 'ESTIMATED'}}
Updated at
2023-03-16
1 organization
1 product
1 drug
1 indication
Organization
University of SydneyProduct
N-acetyl cysteineIndication
Alcohol Use DisorderDrug
Varlilumab