Clinical trial
Comparison of Orally Dissolving Carbidopa/Levodopa (Parcopa) to Conventional Oral Carbidopa/Levodopa: A Single-Dose, Double-Blind, Double-Dummy, Placebo-Controlled, Crossover Trial
Name
H-19596
Description
To find out if a single dose of Parcopa®, a form of levodopa that dissolves in your mouth, works faster than regular oral levodopa which is swallowed, in fluctuating PD patients.
Trial arms
Trial start
2006-10-01
Estimated PCD
2008-10-01
Trial end
2008-11-01
Status
Completed
Phase
Early phase I
Treatment
Parcopa
at subjects current stable dose of comparator
Arms:
Randomization Group b
carbidopa-levodopa (Sinemet)
at subjects current stable dose
Arms:
Randomization Group a
Size
20
Primary endpoint
Measurement of Time in Minutes From When a Patient Was in a Clinical "Off" State, Took Their Medication and Went Into a Clinical "on" State
first dose of day for each arm
Eligibility criteria
Inclusion Criteria:
* Male or female between the age of 31 and 80 -Diagnosis of idiopathic Parkinson's disease for at least three years duration
* Patients requiring levodopa for their PD
* Good subjective response to levodopa
* Fluctuating symptoms defined by wearing off phenomenon, any dyskinesia, and/or dose failures
* A UPDRS -off- motor score of at least 25
* Subjects willing to give informed consent
* Subjects who are able and willing to comply with study procedures
* If female of child-bearing potential, will use one of the approved birth control measures:
1. Hormonal contraceptives
2. Spermicidal and barrier
3. Intrauterine device
4. Partner sterility
Exclusion Criteria:
* Subjects with evidence of significant dementia
* Subjects with significant oral lesions
* History of unstable cardiac disease including angina or congestive heart failure within 3 months prior to study entry
* History of clinically significant renal disease including renal insufficiency of sufficient degree to require adjunctive treatment or dietary restrictions
* History of clinically significant hepatic disease, including previously documented cirrhosis or hepatic insufficiency or jaundice within 3 months prior to study entry.
* Subjects with poor response to levodopa
* Women who are pregnant, breast-feeding, or planning to become pregnant during this study are excluded from participation due to unknown effects of the study drug on the fetus.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'CROSSOVER', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 20, 'type': 'ACTUAL'}}
Updated at
2023-03-14
1 organization
2 products
1 indication
Organization
Baylor College of MedicineProduct
ParcopaIndication
Parkinson's DiseaseProduct
Carbidopa-Levodopa