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Clinical trial

Primary Failure of Eruption (PFE) : Highlighting of Clinical, Radiological and Genetic Diagnostic Criteria: Consequences on the Therapeutic Management

ID
Name
6641
Description
The primary purpose of the study is to identify clinical, radiological and genetic diagnostic criteria for Primary Failure of Eruption (PFE). The secondary purposes are to highlight the genotype-phenotype correlations in the PTHR1 and non-PTHR1 forms and analyze the therapeutic failures.
Trial arms
Trial start
2018-10-22
Estimated PCD
2023-10-12
Trial end
2023-10-12
Status
Recruiting
Treatment
genetic analysis
saliva is collected for DNA extraction
panoramic radiography
panoramic radiography
teleradiography
teleradiography
intraoral X-rays
intraoral X-rays
CT scan of maxillary and mandible
CT scan of maxillary and mandible
Size
50
Primary endpoint
Number of teeth
at inclusion (day 1)
Recording of dental caries
at inclusion (day 1)
Recording the location of dental caries
at inclusion (day 1)
Drugs intra uterine exposure
at inclusion (day 1)
Nutritional deficiencies
at inclusion (day 1)
Periodontium
at inclusion (day 1)
Oral hygiene
at inclusion (day 1)
Gingival inflammation
at inclusion (day 1)
Treatment needs
at inclusion (day 1)
Face shape
at inclusion (day 1)
Symmetry of the face
at inclusion (day 1)
Profile (shape)
at inclusion (day 1)
Smile
at inclusion (day 1)
Vertical dimension
at inclusion (day 1)
Transversal dimension
at inclusion (day 1)
Sagittal dimension
at inclusion (day 1)
Chewing
at inclusion (day 1)
Nasal breathing
at inclusion (day 1)
Swallowing
at inclusion (day 1)
Eligibility criteria
Inclusion criteria: * people over 6 years old * people with Primary Failure Eruption Exclusion criteria: * children under 6 years old * endocrine pathology that may interfere with dental eruption * rickets * chemotherapy / radiotherapy * bisphosphonate treatment
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'interventionModelDescription': 'single group', 'primaryPurpose': 'DIAGNOSTIC', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 50, 'type': 'ESTIMATED'}}
Updated at
2023-08-21

1 organization

1 product

1 indication

Organization
University Hospital
Product
Genetic Analysis
Indication
Primary Failure of Eruption