Clinical trial

The Evidence of Early Childhood Caries Prediction by Salivary Cystatin S Levels in a Group of Egyptian Children: A Case Control Study

Name

PEDO 1-2-1

Description

Aim of the study 1. Measuring the levels of salivary cystatin S protein and salivary buffering capacity to determine their relation to early childhood caries. 2. Predection of early childhood caries by using salivary cystatin S levels with demographic, clinical and nutrition habits characteristics of the participants.

Trial arms

Trial start

2023-03-01

Estimated PCD

2023-05-01

Trial end

2023-07-01

Status

Not yet recruiting

Treatment

Measurement of salivary cystatin S protein levels in saliva

The human cystatin S enzyme-linked immunosorbent assay (ELISA) kit will be used to measure the amounts of cystatin S in saliva for cases and controls

Arms:

Caries free children aged between 36-71 month, Children with early childhood caries aged between 36-71 month

Size

Primary endpoint

Levels of salivary cystatin S protein

2 months

Eligibility criteria

Inclusion Criteria: * Medically free children aged 36 to 71 months with one or more decayed (noncavitated or cavitated lesions), missing, or filled teeth due to caries in any primary tooth(cases). * Medically free children aged 36 to 71 months with no decayed, missing, or filled teeth due to caries in any primary tooth(controls). Exclusion Criteria: * Children receiving antibiotic therapy within three month and fluoride prophylaxis within one year. * Parents who will refuse to participate or refuse to sign the informed consent. * Children who will not agree or cooperate with participation.

Protocol

{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'CASE_CONTROL', 'timePerspective': 'RETROSPECTIVE'}, 'enrollmentInfo': {'count': 30, 'type': 'ESTIMATED'}}

Updated at

2023-02-08

1 organization

1 product

1 indication

Organization

Cairo University

Product

Salivary Cystatin S Protein

Indication

Early Childhood Caries