Research on Translational Outcomes of Alcohol (Project RETRO)

STUDY00009051

The primary aim of the current study is to assess the effect of a single dose of carbidopa-levodopa on ad libitum alcohol consumption and alcohol craving in young adults with a history of binge drinking.

2023-02-01

2023-08-01

2023-08-01

Withdrawn

Early phase I

Inclusion Criteria: * Enrolled in 2- or 4-year college program * Currently living in the Seattle Metropolitan area * Have at least two or more episodes of heavy episodic drinking (4/5 or more drinks in a 2 hours for women/men) in the past 30 days. Exclusion Criteria: * Exclusion criteria include: * past-month severe alcohol or other substance use disorders, * mood or anxiety disorder * suicidal ideation * risk of psychotic disorders * excessive alcohol use reaching a Blood Alcohol Level greater than .30% * history of serious medical conditions, regular use of prescription psychotropic or pain medication * history of negative reactions to alcohol * history of treatment for alcohol use disorder * pregnancy or nursing. * use of non-selective monoamine oxidase inhibitors in the past 2 weeks. * narrow-angle glaucoma * undiagnosed skin lesions, * have a history of melanoma, cardiac issues or peptic ulcer. * Currently taking or prescribed any form of levodopa or D2 agonists, D2 antagonists, isoniazid, methylphenidate, bupropion, Viagra, or phosphodiesterase inhibitors.

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}}, 'enrollmentInfo': {'count': 0, 'type': 'ACTUAL'}}

2023-02-13