Role of Anabolic Steroid and Propranolol in Paediatric Burn- A Randomized Controlled Trial

126/RC/KEMU

propranolol and anabolic steroids have a role in pediatric burn patients and their combined effects are to be studied here. They decrease the catabolic response to burn trauma and minimize the duration of growth arrest hence improving the outcome

2020-12-01

2023-09-28

2023-09-28

Recruiting

114

Inclusion Criteria: * Patients presenting within 48 hours of burn * more than 20% and less than 40 %of TBSA burn (measured via modified rule of nine for pediatric burn according to age) * age 2-12 years (as safety of anabolic steroids is not established in \<2years of age) * Scald and flame burn Exclusion Criteria: * Diabetics (diagnosed before hospital admission) * Renal disease (diagnosed before hospital admission) * Asthmatics (on medication previously) * Cardiac anomalies (previously diagnosed) * Patients requiring cardiac support (norepinephrine, dobutamine at any dose and dopamine \>7ug/kg). * All 4 limbs burnt

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'FACTORIAL', 'interventionModelDescription': 'Three groups are made. one will receive steroid (control group). other will receive propranolol and third will receive both propranolol and steroid. their results will be compared', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}}, 'enrollmentInfo': {'count': 114, 'type': 'ESTIMATED'}}

2023-04-10