Double-Blind, Placebo-Controlled Trial of Leptin Replacement Therapy in Patients With Lipodystrophy

0502-294

Lipodystrophies represent a therapeutic challenge with regards to insulin resistance, hypertriglyceridemia and fatty liver which often is coupled with significant adipose tissue loss. The purpose of the study is to examine the safety and efficacy of Leptin on subjects with lipodystrophy.

2006-04-01

2014-11-01

2014-11-01

Completed

Early phase I

25

Inclusion Criteria: * age \> 6 years * Partial and generalized lipodystrophy * Serum leptin levels less than the 7th percentile of normal values reported by the 3rd National Health and Nutrition Examination survey (less than 7.0 ng/mL in females and less than 3/0 ng/mL in males) * Presence of at least one of the following metabolic abnormalities: 1. Type 2 Diabetes Mellitus 2. Fasting serum insulin \>20 uU/mL 3. Fasting serum triglycerides \> 300 mg/dL 4. Previous participation in leptin trial (Amgen 991265, GCRC 660) - for Part B of the Study. Exclusion Criteria: * Known liver disease due to causes other than non-alcoholic steatohepatitis. * Hematocrit of less than 30%. * Current alcohol or substance abuse. * Use of anorexigenic drugs, anabolic steroids, GH and thiazolidinediones * Active tuberculosis * Psychiatric disorder impeding competence or compliance * Malignancies * HIV infection * Subjects who have a known hypersensitivity to E. Coli derived proteins * Other condition, which in the opinion of the clinical investigators would impede completion of the study.

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2024-03-27