Clinical trial
Interventional Study of Growth Hormone Replacement Therapy in Retired Professional Football Players With Growth Hormone Deficiency
Name
UTN: U1111-1201-5972
Description
This is a randomized, double-blind, placebo-controlled, parallel-group trial with an open-label extension to evaluate the efficacy of growth hormone (GH) on cognitive functions of retired professional football players with growth hormone deficiency (GHD).
Trial arms
Trial start
2019-10-08
Estimated PCD
2025-03-01
Trial end
2026-09-01
Status
Recruiting
Phase
Early phase I
Treatment
Growth Hormone
Daily self-injections by subjects:
1-year double-blind phase; 6-month open-label extension for those who received placebo during the double-blind phase
Arms:
Growth Hormone
Other names:
Norditropin® (somatropin [rDNA origin] injection)
Placebo
Daily self-injections by subjects:
1-year double-blind phase
Arms:
Saline
Size
42
Primary endpoint
Cognitive functions- Working Memory
From baseline to 1-year post-treatment
Cognitive functions- Processing Speed
From baseline to 1-year post-treatment
Cognitive functions- Executive Function.
From baseline to 1-year post-treatment
Cognitive functions- Verbal learning and memory
From baseline to 1-year post-treatment
Cognitive functions- ANAM ( Automated Psychological Assessment Metrics)
From baseline to 1-year post-treatment
Eligibility criteria
Inclusion Criteria:
* The subject is willing to provide a signed and dated informed consent indicating that he understands the purpose and procedures required for the study and is willing to participate in the study.
* Former NFL player
* At least one year since retirement from football
* Less than 76 years of age
* Diagnosis of GHD on clinical grounds by a neurologist and an endocrinologist GHD
Exclusion Criteria:
* History of pre-existing brain disease other than concussion or TBI
* History of a premorbid disabling condition that interferes with outcome assessments
* Contraindication to GH therapy
* Type I and II Diabetes mellitus
* Active malignant disease
* Acute critical illness, heart failure, or acute respiratory failure
* Subjects who are deficient in cortisol, testosterone or thyroid at screening will be excluded until hormone abnormalities have been corrected.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'A randomized, double-blind, placebo-controlled trial with an open-label extension', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'TRIPLE', 'maskingDescription': '3-D printing used to design matching cases (covers) for both the drug and placebo autoinjector pens', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 42, 'type': 'ESTIMATED'}}
Updated at
2023-02-08
1 organization
1 product
7 indications
Organization
Center for Neurological StudiesProduct
Growth HormoneIndication
Traumatic Brain InjuryIndication
ConcussionIndication
BrainIndication
Sports InjuryIndication
HypopituitarismIndication
Growth Hormone Deficiency