Clinical trial
Phase II Open-label, Multicentre, Exploratory Trial of Neoadjuvant Dalpiciclib in Combination With Exemestane and Trastuzumab Plus Pyrotinib in Early Triple Positive Breast Cancer
Name
ZYYY-BC-001
Description
This is a phase II open-label, multicenter trial assessing the efficacy of combination regimen"Dalpiciclib plus Exemestane plus trastuzumab plus pyrotinib"in early triple positive breast cancer patients.
Trial arms
Trial start
2022-09-01
Estimated PCD
2024-12-01
Trial end
2024-12-01
Status
Recruiting
Phase
Early phase I
Treatment
Trastuzumab Pyrotinib Exemestane Dalpiciclib
Early triple positive breast cancer patients receive combination regimen of Dalpiciclib in Combination With Exemestane and Trastuzumab plus pyrotinib
Arms:
Dalpiciclib in combination with exemestane and trastuzumab plus pyrotinib
Other names:
Herceptin Pyrotinib Aromasin Dalpiciclib
Size
30
Primary endpoint
pathological complete response (pCR)
at surgery
Eligibility criteria
Inclusion Criteria:
* 18 Years to 75 Years
* Newly diagnosed clinical stage II or III ER+/HER2+ breast cancer, staging criteria is to be based on AJCC 7.
* Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1
* Primary tumor must have positive estrogen receptor (ER) ≥10%
* Primary tumor must be HER2-positive (IHC 3+ or FISH/CISH amplification)
* Baseline LVEF ≥50% measured by Echocardiography (preferred) or MUGA scan
* Normal organ and marrow function
* Written Informed Consent (IC) must be signed and dated by the patient and the Investigator prior to randomization.
* Baseline corrected QT interval (QTcF) \< 480 ms
* All patients must be female.
Exclusion Criteria:
* Inflammatory breast cancer
* Evidence of bilateral invasive breast cancer or metastatic disease
* Received any prior treatment for primary invasive breast cancer
* Pregnant or lactating women
* Abnormal baseline hematological values:
* Abnormal baseline liver function, bilirubin, creatinine and/or INR (international normalized ratio)
* Subjects with known infection with HIV, HBV, HCV
* Other investigational drugs while on study
* Severe or uncontrolled hypertension, history of congestive heart failure or severe coronary arterial disease.
* Subjects assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 30, 'type': 'ESTIMATED'}}
Updated at
2023-02-21
1 organization
1 product
3 indications
Organization
First Affiliated Hospital of Zhejiang UniversityIndication
Breast CancerIndication
Estrogen Receptor Positive TumorIndication
Breast Cancer (HER2-positive)