Clinical trial
A Phase 1, Open-Label, Single-Dose, Parallel-Group Study of the Pharmacokinetics and Safety of VIR-2218 in Adult Participants With Renal Impairment
Name
VIR-2218-V108
Description
The rationale of this study is to evaluate the impact of renal function on the PK, safety, and tolerability of VIR-2218 in participants with normal renal function and participants with varying degrees of renal dysfunction who are otherwise medically stable
Trial arms
Trial start
2023-06-01
Estimated PCD
2025-05-15
Trial end
2025-11-21
Status
Recruiting
Phase
Early phase I
Treatment
VIR-2218
VIR-2218 given by subcutaneous injection
Arms:
Cohort 1: 8 moderate Renal Impairment (RI) participants and 8 matched healthy participants, Cohort 2: 8 severe Renal Impairment (RI) participants and 8 matched healthy participants (optional)
Size
32
Primary endpoint
Maximum Observed Plasma Concentration (Cmax) of VIR-2218 and its metabolite AS(N-1)3'VIR-2218
5 days
Area Under The Plasma Concentration-time Curve from Time Zero to Time of Last Quantifiable Concentration (AUClast) of VIR-2218 and metabolite AS(N-1)3'VIR-2218
5 days
Area Under the Plasma Concentration-time Curve from Time Zero to Infinity (AUCinf) of VIR-2218 metabolite AS(N-1)3'VIR-2218
5 days
Fraction excreted in urine in percentage for VIR-2218 and its metabolite AS(N-1)3'VIR-2218
5 days
Amount excreted in urine for VIR-2218 and its metabolite AS(N-1)3'VIR-2218
5 days
Renal clearance for VIR-2218 and its metabolite AS(N-1)3'VIR-2218
5 days
Eligibility criteria
Inclusion Criteria for All Participants:
* Participants must have stable renal function as defined by less than 20% change in estimated glomerular filtration rate (eGFR) between the first and second screening sample with the first screening visit occurring within 28 days prior to dosing on Day 1 and the second screening visit occurring no more than 14 days apart, but at least 72 hours apart from the first.
* Body mass index (BMI) within the range 18.5 to 35.0 kg/m2 at screening.
* Female and Male participants must consent to follow contraception requirements
* Capability of giving signed informed consent form
Inclusion Criteria: Additional Criteria Specific to Healthy Participants:
* Must be in the opinion of the investigator, be in good health based upon medical history, vital signs, physical examination, and screening laboratory evaluations
* Must have normal renal function as defined by eGFR ≥ 90 mL/min/1.73m2 based on the Modification of Diet in Renal Disease (MDRD) equation determined from the mean of two measurements of serum creatinine at screening.
Inclusion Criteria: Additional Criteria Specific to Participants with Renal Impairment
* Participants must, in the opinion of the investigator, be sufficiently healthy for study participation based on medical history, physical examination, vital signs, and screening laboratory evaluations
* Participants with RI must have chronic moderate or severe RI and be clinically stable per investigator assessment for at least 3 months prior to screening
* Moderate RI as defined by eGFR level 30-59 mL/min/1.73m2 based on the MDRD equation, or
* Severe RI as defined by eGFR level 15-29 mL/min/1.73m2 based on the MDRD equation
Exclusion Criteria: Criteria for All Participants
* Any clinically significant medical condition or psychiatric condition that may interfere with study intervention
* Participants with uncontrolled hypertension, asthma, and/or diabetes (Type I or II).
* Participants with diabetes
* Participants with any active malignancy
* Participants with vasculitis or conditions associated with vasculitis.
* Participants who have undergone major surgery within 12 months of screening
* Participants with unstable cardiac functions, abnormality, or clinically significant heart failure
* Participants with infection of HIV, HAV, HBV, HCV, HDV, or HEV
* Participants with signs of active infection
* History of bone marrow or solid organ transplantation
* Participants with end-stage renal disease or nephrotic syndrome as defined by: participants requiring hemodialysis or peritoneal dialysis, participants who have undergone or are listed for transplant, or participants who have chronic kidney disease with nephrotic syndrome
* Participants with active nephritis
* Participants with clinically significant liver disease
* History of drug or alcohol abuse
* Unwillingness or inability to follow procedures outlined in protocol
Exclusion Criteria: Additional Criteria Specific to Healthy Participants
* Use of any prescription medications or over-the-counter medications (with the exception of vitamins and/or hormonal contraceptive medications) including herbal products within 30 days prior to D1 of study participation
Exclusion Criteria: Additional Criteria Specific to Participants with Renal Impairment
* Not on stable dose and regimen of any medication(s) (prescription or over-the-counter) that the participants is taking regularly (eg, medications for chronic conditions such as hypertension, high cholesterol, or depression must not be changed in dose or type for at least 2 weeks prior to study drug administration)
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'NON_RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 32, 'type': 'ESTIMATED'}}
Updated at
2024-05-03
1 organization
1 product
1 indication
Organization
Vir BiotechnologyProduct
VIR-2218Indication
Renal Impairment