The Occurrence of Single Nucleotide Polymorphism Among Women Who Experienced Obstetric Anal Sphincter Injury

0091-18-EMC

Single-nucleotide polymorphisms (SNP's) in connective tissue components are associated with increased risk of pelvic organ prolapse (POP). The investigators expect to find a difference in SNP's frequency between women who had Obstetric anal sphincter injuries (OASIS) and in the healthy population. The fact that pelvic organ prolapse (POP) and OASIS occurs in the same anatomic region and the well-known association between few SNP's and the risk for POP, suggests for a common pathophysiology.

2020-09-04

2023-10-05

2023-10-05

Completed

93

Inclusion Criteria: * Women with severe external anal sphincter injury during first vaginal delivery * Healthy women undergoing vaginal delivery without any clinically apparent perineal laceration Exclusion Criteria: * Women with known metabolic or connective-tissue disorder (e.g., Ehlers-Danlos syndrome). * Women with known neurologic disorder * Women undergoing episiotomy cut or assisted delivery (e.g., vacuum or forceps delivery)

{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'NON_RANDOMIZED', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'two arms -\n\n1. with external anal sphincter injury\n2. without injury both will go through genetic screening test the arm with the external anal sphincter injury will also be tested for advanced genetic testing', 'primaryPurpose': 'SCREENING', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 93, 'type': 'ACTUAL'}}

2024-02-28