Methylphenidate and Response to Alcohol Cues (MARA) Pilot Study

IRB202301428

The purpose of this study is to determine whether changes in attention levels related to taking a single dose of a medication called methylphenidate, also known as Ritalin, affects responses to alcohol cues. The study will observe the effects of methylphenidate or a placebo on attentional bias and craving responses to alcohol cues through fMRI, EEG, and behavioral testing. Participants will be involved in one remote and two in-person sessions.

2024-03-20

2025-06-01

2025-06-01

Recruiting

Early phase I

30

Inclusion Criteria: * Adults ages 18-25 years * Meets DSM-5 criteria for AUD * Meets DSM-5 criteria for ADHD * Fluent in English * Normal or corrected to normal vision Exclusion Criteria: * Meets DSM-5 criteria for bipolar disorder, psychotic disorders, neurological disorders, or substance use disorders other than AUD. * Participant routinely uses psychoactive drugs or medications except for non-dependent marijuana or nicotine use (due to common use of these substances in individuals with AUD). * Participant has contraindications for taking methylphenidate. * Participant has contraindications for being in an MRI machine * Self-reported history of high blood pressure over 140/90 or consistent readings of 140/90 or above upon arrival for a session. * History of seizure disorder * Liver disease * Participant is currently pregnant or trying to become pregnant

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2024-05-02