The Effect of Central Insulin on Insulin Sensitivity and Energy Metabolism

Centrin

Insulin has a direct effect on the energy metabolism of the brain under basal conditions and has an effect on the hepatic glucose production, lipid metabolism and the secretion of various hormone. The effect of intranasal insulin on peripheral metabolism in humans supposedly is mediated by the vagus nerve. The purpose of this study is to determine whether central insulin influences the human peripheral insulin sensitivity of liver and muscle and whether vagus nerve stimulation can mimick this effect.

2011-08-01

2014-01-01

2014-06-01

Completed

Early phase I

30

Inclusion Criteria: * Age ≥ 30 and ≤ 70 years * balanced gender ratio (50: 50) * BMI 20-25 kg/m² (normal weight subjects) * BMI 25-35 kg/m² (obese subjects) Exclusion Criteria: * acute illness within the last 2 weeks before the examination * autoimmune diseases and disorders immune- compromised (leukocytes \<5000/μl) * renal insufficiency (creatinine\> 1.5 mg / dl) * heart disease, condition after heart attack * anemia (Hb \<12 g / l, controls at each examination), blood donation within 4 weeks before the examination * participation in another study within 2 months before the examination * wear a metal or magnetic objects on or in the body * claustrophobia * use of immunomodulatory drugs (cortisol, antihistamines, aspirin) * thyroid disease * taking glitazones and insulin therapy * pregnancy, lactation, menstruation * cigarette smoking, use of alcohol or drugs, psychiatric disorders * risk for / or manifest AIDS (HIV) or hepatitis B or C * liver disease is not attributed to the existence of a non-alcoholic steatosis * night shift work or circumstances, which do not allow the normal day-night rhythm * bleeding disorders or disorders in wound healing * hypersensitivity to local anesthetics * malignant cancer * heart rhythm disorders * polyneuropathy

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2023-06-05