Ulinastatin Improves Post-Cardiac Surgery Cognitive Dysfunction by Inhibiting Glycocalyx Degradation: An Observational Study

TJ-IRB20231224

This study is a retrospective, observational study that aims to include patients undergoing cardiac surgery. 1. Evaluate the preventive effect of ursodeoxycholic acid on post-cardiac surgery cognitive dysfunction over the past eight years. 2. Utilize the pre-existing preoperative and postoperative 24-hour plasma samples from previous studies to measure the levels of glycocalyx and its related regulatory factors. 3. Assess the clinical correlation between the measured parameters and patient outcomes.

2015-01-01

2022-12-30

2023-12-30

Completed

7065

Inclusion Criteria: 1. Voluntary participation in the study; 2. Age ≥ 18 years and ≤ 80 years; 3. Patients undergoing heart surgery: (coronary artery bypass grafting, heart valve replacement surgery, Morrow procedure, aortic dissection surgery). Exclusion Criteria: 1. Patients experiencing adverse events during the surgery; 2. Recipients of solid organ or bone marrow transplants; 3. Patients with autoimmune diseases, tumors, or who have received high-dose steroids or immunosuppressive therapy within the past 2 months; 4. Deemed unsuitable for participation in this study by the researchers.

{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'COHORT', 'timePerspective': 'RETROSPECTIVE'}, 'enrollmentInfo': {'count': 7065, 'type': 'ACTUAL'}}

2024-02-20